C3 heterocyle indenopyrazole 8n

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: C3 heterocyle indenopyrazole 8n
• 英文别名: 1-[3-(2,4-dimethyl-1,3-thiazol-5-yl)-4-oxo-2H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea
• 化学式: C₂₀H₂₀N₆O₃S
• 分子量: 424.483
• InChiKey: NWEQNXJINNWDOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,4-二甲基-5-乙酰基噻唑 在 水 、 乙酸酐 、 sodium carbonate 、 三乙胺 、 calcium chloride 、 肼 、 锌 作用下， 以 乙醇 、 二甲基亚砜 、 丙酮 为溶剂， 生成 C3 heterocyle indenopyrazole 8n
  参考文献：
  名称：

  Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3

  摘要：

  New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.

  DOI：

  10.1016/j.bmcl.2003.11.008

文献信息

• Indeno [1,2-c]pyrazol-4-ones and their uses
  申请人：——

  公开号：US20010027195A1

  公开（公告）日：2001-10-04

  The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1 that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

  本发明涉及合成一种新类别的indeno[1,2-c]pyrazol-4-ones化合物，其化学式为(I):1，这些化合物是一类名为细胞周期依赖性激酶的酶的强效抑制剂，与催化亚基cdk1-9及其调节亚基cyclins A-H有关。本发明还提供了一种新颖的治疗癌症或其他增生性疾病的方法，即通过给予这些化合物中的一种或其药用可接受的盐形式的治疗有效剂量。另外，可以通过给予本发明化合物之一与一种或多种其他已知的抗癌或抗增生剂的治疗有效组合来治疗癌症或其他增生性疾病。
• 3- (2,4-dimethylthiazol-5-yl) indeno [1,2-c]pyrazol-4-one derivatives and their uses
  申请人：——

  公开号：US20020107274A1

  公开（公告）日：2002-08-08

  The present invention relates to 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-ones of formula 1 which are potent inhibitors of cyclin dependent kinases. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

  本发明涉及式1的3-(2,4-二甲基噻唑-5-基)吲哚并[1,2-c]吡唑-4-酮类化合物，这些化合物是强效的细胞周期依赖性激酶抑制剂。本发明还提供了一种新的方法，通过给予这些化合物或其药学上可接受的盐形式的治疗有效量，来治疗癌症或其他增生性疾病。另外，还可以通过给予本发明化合物中的一种或多种其他已知的抗癌或抗增生药物的治疗有效组合，来治疗癌症或其他增生性疾病。
• US6407103B2
  申请人：——

  公开号：US6407103B2

  公开（公告）日：2002-06-18
• US6706718B2
  申请人：——

  公开号：US6706718B2

  公开（公告）日：2004-03-16
• Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3
  作者：Eddy W. Yue、Susan V. DiMeo、C.Anne Higley、Jay A. Markwalder、Catherine R. Burton、Pamela A. Benfield、Robert H. Grafstrom、Sarah Cox、Jodi K. Muckelbauer、Angela M. Smallwood、Haiying Chen、Chong-Hwan Chang、George L. Trainor、Steven P. Seitz

  DOI：10.1016/j.bmcl.2003.11.008

  日期：2004.1

  New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.