δ-Glutamyl-p-nitroanilid | 24032-35-7

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 谷氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: δ-Glutamyl-p-nitroanilid
• 英文别名: L-glutamic acid 1-(4-nitroanilide)；(S)-4-amino-5-[(4-nitrophenyl)amino]-5-oxovaleric acid；4-azaniumyl-5-(4-nitroanilino)-5-oxopentanoate
• CAS: 24032-35-7
• 化学式: C₁₁H₁₃N₃O₅
• 分子量: 267.241
• InChiKey: JXQXNQKTUGNZLD-UHFFFAOYSA-N

物化性质

• 熔点：
  184-186 °C
• 沸点：
  592.4±50.0 °C(Predicted)
• 密度：
  1.463±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2924299090

制备方法与用途

用途：用于生化研究，特别是作为氨肽酶A（aminopeptidase A）的显色底物，在410 nm波长下测定酶催化产生的4-硝基苯胺的释放量。

文献信息

• A process for the identification of bacteria and a kit of reagents for use in this process
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0018825A1

  公开（公告）日：1980-11-12

  A procedure for identification of bacteria comprises subjecting the bacteria to a combination of tests for determination of 26 bacterial enzymes, permitting rapid identification by use of tests generally adapted for determination of constitutive enzymes. The procedure generally permits more rapid identification than previous bacterial identification procedures and is universally applicable to a very wide range of bacteria including most bacteria which are commonly encountered clinically. In a particular embodiment the invention includes a procedure for rapid differentation of the bacterial groups Escherichia, Klebsiella spp., Proteus and Pseudomonas spp., comprising subjecting the bacteria to a combination of tests for determination of bacterial acid phosphatase. beta-galactosidase, glutamate decarboxylase, phenylalanine deaminase, cytochrome oxidase, diacetyl producing enzymes and urease. Additionally the invention includes kits for carrying out the procedures of the invention. typically comprising separate specific substrates for each of the enzymes which it is desired to determine, the kit being preferably in the form of a test card or other suitable apparatus comprising a plurality of wells or compartments which separately contain the enzyme substrates.

  细菌鉴定程序包括对细菌进行测定 26 种细菌酶的组合试验，通过使用一般适用于测定组成酶的试验，可快速鉴定细菌。与以前的细菌鉴定程序相比，该程序一般能更快地鉴定细菌，而且普遍适用于各种细菌，包括临床上常见的大多数细菌。在一个特定的实施方案中，本发明包括一种用于快速鉴别埃希氏菌、克雷伯氏菌属、变形杆菌和假单胞菌属细菌的程序，包括对细菌进行测定细菌酸性磷酸酶、β-半乳糖苷酶、谷氨酸脱羧酶、苯丙氨酸脱氨酶、细胞色素氧化酶、双乙酰产酶和脲酶的组合试验。此外，本发明还包括用于执行本发明程序的试剂盒。试剂盒通常包括用于需要测定的每种酶的单独特异性底物，试剂盒最好采用测试卡或其他适当装置的形式，该装置包括多个分别含有酶底物的孔或隔室。
• COMBINATORY TREATMENT FOR LYMPHOMA
  申请人：Université de Paris

  公开号：EP3892267A1

  公开（公告）日：2021-10-13

  The invention relates to the field of medicine and more particularly to novel combinations and combinatory treatments useful for treating lymphoma. More particularly, the invention thus relates to a combination comprising at least one inhibitor of glutamine metabolism or a pharmaceutically acceptable salt, prodrug, derivative, or sustained release formulation thereof and at least one inhibitor of mitochondrial electron transport chain or a pharmaceutically acceptable salt, prodrug, derivative, or sustained release formulation thereof, for its use in the treatment or the prevention of a lymphoma in a subject in need thereof.

  本发明涉及医学领域，尤其涉及治疗淋巴瘤的新型组合物和联合疗法。更具体地说，本发明涉及一种组合物，该组合物包含至少一种谷氨酰胺代谢抑制剂或其药学上可接受的盐、原药、衍生物或缓释制剂，以及至少一种线粒体电子传递链抑制剂或其药学上可接受的盐、原药、衍生物或缓释制剂，用于治疗或预防有需要的受试者的淋巴瘤。
• STIMULI-RESPONSIVE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20190117799A1

  公开（公告）日：2019-04-25

  Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.
• US4603108A
  申请人：——

  公开号：US4603108A

  公开（公告）日：1986-07-29