7a-methyl-hexahydro-3,7-cyclo-cyclopenta[c]pyran-1-one | 30244-06-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7a-methyl-hexahydro-3,7-cyclo-cyclopenta[c]pyran-1-one
• 英文别名: 3a-methylhexahydro-3H-1,4-methanocyclopenta[c]furan-3-one；2-exo-Hydroxy-7-methyl-7-norbornanecarboxylic acid 7-lactone；6-methyl-4-oxatricyclo[4.3.0.03,7]nonan-5-one
• CAS: 30244-06-5
• 化学式: C₉H₁₂O₂
• 分子量: 152.193
• InChiKey: HGUNJLUBYIIFBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  7a-methyl-hexahydro-3,7-cyclo-cyclopenta[c]pyran-1-one 在 lithium aluminium tetrahydride 、 sodium iodide 作用下， 生成 (1S,4S,7R)-7-Iodomethyl-7-methyl-bicyclo[2.2.1]heptan-2-one
  参考文献：
  名称：

  Collins,P.A.; Wege,D., Australian Journal of Chemistry, 1979, vol. 32, p. 1819 - 1826

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-2-methyl-norborn-5-ene-2exo-carboxylic acid 在 硫酸 作用下， 以 水 为溶剂， 以73%的产率得到7a-methyl-hexahydro-3,7-cyclo-cyclopenta[c]pyran-1-one
  参考文献：
  名称：

  [EN] BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS
  [FR] DERIVES D'INDOLYLE BICYCLIQUES, ET PROCEDES RELATIFS A LEUR UTILISATION COMME AGENTS SEROTONERGIQUES

  摘要：

  本文披露了双环吲哚衍生物及含有这种化合物的组合物。还披露了使用双环吲哚衍生物和含有这种组合物作为5-羟色胺能药物的方法，例如用于治疗抑郁症和焦虑症。此外，还披露了制备双环吲哚衍生物的过程。

  公开号：

  WO2004111035A1

文献信息

• Bicyclic indolyl derivatives and methods for their use as serotonergic agents
  申请人：Kelly G. Michael

  公开号：US20050124630A1

  公开（公告）日：2005-06-09

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本发明公开了双环吲哚衍生物和含有这些化合物的组合物。还公开了使用双环吲哚衍生物和含有这种组合物作为血清素能药物的方法，例如用于治疗抑郁症和焦虑症。此外，还公开了制备双环吲哚衍生物的方法。
• Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents
  申请人：Kelly Gerard Micahel

  公开号：US20070135445A1

  公开（公告）日：2007-06-14

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本发明揭示了双环吲哚衍生物及含有这种化合物的组合物。本发明还揭示了使用双环吲哚衍生物和含有这种组合物作为5-羟色胺能药物的方法，例如在治疗抑郁和焦虑方面。此外，本发明还揭示了制备双环吲哚衍生物的方法。
• BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS
  申请人：Wyeth

  公开号：EP1644355A1

  公开（公告）日：2006-04-12
• US7179813B2
  申请人：——

  公开号：US7179813B2

  公开（公告）日：2007-02-20
• [EN] BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS<br/>[FR] DERIVES D'INDOLYLE BICYCLIQUES, ET PROCEDES RELATIFS A LEUR UTILISATION COMME AGENTS SEROTONERGIQUES
  申请人：WYETH CORP

  公开号：WO2004111035A1

  公开（公告）日：2004-12-23

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本文披露了双环吲哚衍生物及含有这种化合物的组合物。还披露了使用双环吲哚衍生物和含有这种组合物作为5-羟色胺能药物的方法，例如用于治疗抑郁症和焦虑症。此外，还披露了制备双环吲哚衍生物的过程。