(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl octanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl octanoate
• 英文别名: [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] octanoate
• 化学式: C₂₃H₄₀O₂
• 分子量: 348.6
• InChiKey: HHSVAJNBWYMLPB-QMEDZHDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
  申请人：——

  公开号：US20030129683A1

  公开（公告）日：2003-07-10

  This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.

  本发明提供了一种直接监测细菌转糖基化酶活性的方法，该方法使用化学酶法合成产生的标记底物，其中标记的选择允许同时检测聚合和非聚合产物，可以直接检测，也可以在产物与起始材料分离后检测。本发明通过 a) 为纯化的活性转糖苷酶的结构分析奠定基础（允许基于结构的设计）；b) 提供可用于筛选抑制剂的检测方法，从而促进发现对细菌转糖苷酶有活性的新抗生素。
• BACTERIAL TRANSGLYCOSYLASES: ASSAYS FOR MONITORING THE ACTIVITY USING LIPID II SUBSTRATE ANALOGS AND METHODS FOR DISCOVERING NEW ANTIBIOTICS
  申请人：PRINCETON UNIVERSITY

  公开号：EP1159293A1

  公开（公告）日：2001-12-05
• Host Cells and Methods for Producing Isoprenyl Alkanoates
  申请人：Lee Taek Soon

  公开号：US20100180491A1

  公开（公告）日：2010-07-22

  The invention provides for a method of producing an isoprenyl alkanoate in a genetically modified host cell. In one embodiment, the method comprises culturing a genetically modified host cell which expresses an enzyme capable of catalyzing the esterification of an isoprenol and a straight-chain fatty acid, such as an alcohol acetyltransferase (AAT), wax ester synthase/diacylglycerol acyltransferase (WS/DGAT) or lipase, under a suitable condition so that the isoprenyl alkanoate is produced.
• US6461829B1
  申请人：——

  公开号：US6461829B1

  公开（公告）日：2002-10-08
• US6911318B2
  申请人：——

  公开号：US6911318B2

  公开（公告）日：2005-06-28