γ-Hydroxy-β,γ-dihydroubichinon-(7) | 19721-60-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: γ-Hydroxy-β,γ-dihydroubichinon-(7)
• 英文别名: 2-[(6E,10E,14E,18E,22E)-3-hydroxy-3,7,11,15,19,23,27-heptamethyloctacosa-6,10,14,18,22,26-hexaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• CAS: 19721-60-9
• 化学式: C₄₄H₆₈O₅
• 分子量: 677.021
• InChiKey: PLNVEKPYRYVQJV-UCDCYZMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.6
• 重原子数：
  49
• 可旋转键数：
  23
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS FOR IMPROVING BLOOD GLUCOSE CONTROL
  申请人：Miller Guy M.

  公开号：US20120295985A1

  公开（公告）日：2012-11-22

  The present invention is concerned with a method for improving blood glucose control or for preventing or treating a condition requiring increasing insulin sensitivity or reducing insulin resistance in a subject in need of such control which comprises administering to the subject a composition comprising a therapeutically effective amount of one or more quinones of Formula I.
• FORMULATIONS OF QUINONES FOR THE TREATMENT OF OPHTHALMIC DISEASES
  申请人：Miller Guy M.

  公开号：US20130109759A1

  公开（公告）日：2013-05-02

  A formulation comprising an ophthalmically effective amount of one or more quinones of Formula I. Use of a formulation comprising one or more quinones of Formula I for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more quinones of Formula I is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more quinones of Formula I is also discussed.