3-(4-Hydroxy-4-methyl-pentyl)-1-methyl-cyclohex-2-enol | 284464-11-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-Hydroxy-4-methyl-pentyl)-1-methyl-cyclohex-2-enol
• 英文别名: 3-(4-Hydroxy-4-methylpentyl)-1-methylcyclohex-2-en-1-ol
• CAS: 284464-11-5
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: PODXTAVNRFLQIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-Hydroxy-4-methyl-pentyl)-1-methyl-cyclohex-2-enol 在 amberlyst-15 resin 氢气 作用下， 以 氯仿 为溶剂， 反应 1.0h， 生成 2-Methyl-5-(5-methyl-cyclohexa-1,5-dienyl)-pentan-2-ol
  参考文献：
  名称：

  Amberlyst-15-catalyzed intramolecular SN2′ oxaspirocyclization of tertiary allylic alcohols

  摘要：

  A variety of substituted 1-oxaspiro[4,5]dec-6-ene and 1-oxaspiro[5,5]undec-7-ene systems have been prepared by utilizing Amberlyst-15-catalyzed S(N)2' oxaspirocyclizations under mild reaction conditions (-20 degrees C) in quantitative yields. In this process, a tertiary allylic alcohol serves as the precursor of pi-allylic carbocation and the primary, secondary or tertiary alcohol within the same molecule serves as the nucleophile, (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00390-7
• 作为产物：
  描述：

  3-(4-羟基丁基)-2-环己烯-1-酮 在 chromium(VI) oxide 、 硫酸 作用下， 以 四氢呋喃 、 乙醚 、 丙酮 为溶剂， 生成 3-(4-Hydroxy-4-methyl-pentyl)-1-methyl-cyclohex-2-enol
  参考文献：
  名称：

  Amberlyst-15-catalyzed intramolecular SN2′ oxaspirocyclization of tertiary allylic alcohols

  摘要：

  A variety of substituted 1-oxaspiro[4,5]dec-6-ene and 1-oxaspiro[5,5]undec-7-ene systems have been prepared by utilizing Amberlyst-15-catalyzed S(N)2' oxaspirocyclizations under mild reaction conditions (-20 degrees C) in quantitative yields. In this process, a tertiary allylic alcohol serves as the precursor of pi-allylic carbocation and the primary, secondary or tertiary alcohol within the same molecule serves as the nucleophile, (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00390-7

文献信息

• Amberlyst-15-catalyzed intramolecular SN2′ oxaspirocyclization of tertiary allylic alcohols
  作者：Jenn-jong Young、Liarng-jyur Jung、Kuang-ming Cheng

  DOI：10.1016/s0040-4039(00)00390-7

  日期：2000.4

  A variety of substituted 1-oxaspiro[4,5]dec-6-ene and 1-oxaspiro[5,5]undec-7-ene systems have been prepared by utilizing Amberlyst-15-catalyzed S(N)2' oxaspirocyclizations under mild reaction conditions (-20 degrees C) in quantitative yields. In this process, a tertiary allylic alcohol serves as the precursor of pi-allylic carbocation and the primary, secondary or tertiary alcohol within the same molecule serves as the nucleophile, (C) 2000 Elsevier Science Ltd. All rights reserved.