2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethylamine | 877994-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethylamine
• 英文别名: 2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethan-1-amine；2-(5-Methoxypyrazolo[1,5-a]pyridin-3-yl)ethanamine；2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethanamine
• CAS: 877994-13-3
• 化学式: C₁₀H₁₃N₃O
• 分子量: 191.233
• InChiKey: UKOOOZSXUBIAKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethylamine 、 丁酸酐 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以82%的产率得到N-[2-(5-Methoxy-pyrazolo[1,5-a]pyridin-3-yl)-ethyl]-butyramide
  参考文献：
  名称：

  Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation

  摘要：

  Employing 1,3-dipolar cycloaddition for the synthesis of the 7a-azaindole nucleus, analogues of melatonin have been synthesized and tested against human and amphibian melatonin receptors. Introducing a phenyl substituent ill position 2 of the heterocyclic moiety significantly increased binding affinity to both the MT1 and MT2 receptors. Shifting the methoxy group from position 5 to 2 of the 7a-azaindole ring led to a substantial reduction of MT1 binding when MT2 recognition was maintained. We theoretically investigated the hypothesis whether the 2-methoxy function of the azamelatonin analogue 27 is able to mimic the 5-methoxy group of the neurohormone by directing its 2-methoxy function toward the methoxy binding site. DFT calculations and experimental binding differences of analogue compounds indicate that the energy gained by forming the methoxy-specific hydrogen-bond interaction should exceed the energy required for adopting ail alternative conformation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.10.042
• 作为产物：
  描述：

  5-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde 在 tin 、 sodium tetrahydroborate 、 盐酸甲胺 、 potassium acetate 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 144.83h， 生成 2-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)ethylamine
  参考文献：
  名称：

  Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation

  摘要：

  Employing 1,3-dipolar cycloaddition for the synthesis of the 7a-azaindole nucleus, analogues of melatonin have been synthesized and tested against human and amphibian melatonin receptors. Introducing a phenyl substituent ill position 2 of the heterocyclic moiety significantly increased binding affinity to both the MT1 and MT2 receptors. Shifting the methoxy group from position 5 to 2 of the 7a-azaindole ring led to a substantial reduction of MT1 binding when MT2 recognition was maintained. We theoretically investigated the hypothesis whether the 2-methoxy function of the azamelatonin analogue 27 is able to mimic the 5-methoxy group of the neurohormone by directing its 2-methoxy function toward the methoxy binding site. DFT calculations and experimental binding differences of analogue compounds indicate that the energy gained by forming the methoxy-specific hydrogen-bond interaction should exceed the energy required for adopting ail alternative conformation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.10.042

文献信息

• WO2023/115165
  申请人：——

  公开号：——

  公开（公告）日：——
• Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation
  作者：Jan Elsner、Frank Boeckler、Kathryn Davidson、David Sugden、Peter Gmeiner

  DOI：10.1016/j.bmc.2005.10.042

  日期：2006.3

  Employing 1,3-dipolar cycloaddition for the synthesis of the 7a-azaindole nucleus, analogues of melatonin have been synthesized and tested against human and amphibian melatonin receptors. Introducing a phenyl substituent ill position 2 of the heterocyclic moiety significantly increased binding affinity to both the MT1 and MT2 receptors. Shifting the methoxy group from position 5 to 2 of the 7a-azaindole ring led to a substantial reduction of MT1 binding when MT2 recognition was maintained. We theoretically investigated the hypothesis whether the 2-methoxy function of the azamelatonin analogue 27 is able to mimic the 5-methoxy group of the neurohormone by directing its 2-methoxy function toward the methoxy binding site. DFT calculations and experimental binding differences of analogue compounds indicate that the energy gained by forming the methoxy-specific hydrogen-bond interaction should exceed the energy required for adopting ail alternative conformation. (c) 2005 Elsevier Ltd. All rights reserved.