8-methoxycarbonyloctyl 2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-6-O--β-D-glucopyranoside | 108964-08-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-methoxycarbonyloctyl 2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-6-O--β-D-glucopyranoside
• CAS: 108964-08-5
• 化学式: C₃₆H₆₂N₂O₂₁
• 分子量: 858.889
• InChiKey: ACKJMUNMLIDNDD-KECSJOKMSA-N

反应信息

• 作为反应物：
  描述：

  8-methoxycarbonyloctyl 2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-6-O--β-D-glucopyranoside 在 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 36.0h， 生成 8-methoxycarbonyloctyl 2-acetamido-2-deoxy-6-O-(3,5-diacetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)-4-O-β-D-galactopyranosyl-β-D-glucopyranoside
  参考文献：
  名称：

  Transfer of d-galactosyl groups to 6-O-substituted 2-acetamido-2-deoxy-d-glucose residues by use of bovine d-galactosyltransferase

  摘要：

  Bovine D-galactosyltransferase was found to transfer D-galactose from UDP-galactose to 6-O-substituted 2-acetamido-2-deoxy-beta-D-glucopyranosides. The resulting 6-O-substituted N-acetyllactosamines were readily synthesized in milligram amounts and conveniently isolated on a reverse-phase support when prepared as the 8-methoxycarbonyloctyl glycosides. The 6-O-substitution tolerated by the enzyme include an alpha-L-fucopyranosyl group and the methyl ester of alpha-linked N-acetylneuraminic acid, but not the free acid itself. The product trisaccharides were characterized by 1H-n.m.r. spectroscopy and fast-atom-bombardment mass spectrometry.

  DOI：

  10.1016/s0008-6215(00)90224-6
• 作为产物：
  描述：

  8-methoxycarbonyloctyl 2-acetamido-6-O-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)-2-deoxy-β-D-glucopyranoside, sodium salt 以 水 、 二甲基亚砜 为溶剂， 反应 60.25h， 生成 8-methoxycarbonyloctyl 2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-6-O--β-D-glucopyranoside
  参考文献：
  名称：

  Transfer of d-galactosyl groups to 6-O-substituted 2-acetamido-2-deoxy-d-glucose residues by use of bovine d-galactosyltransferase

  摘要：

  Bovine D-galactosyltransferase was found to transfer D-galactose from UDP-galactose to 6-O-substituted 2-acetamido-2-deoxy-beta-D-glucopyranosides. The resulting 6-O-substituted N-acetyllactosamines were readily synthesized in milligram amounts and conveniently isolated on a reverse-phase support when prepared as the 8-methoxycarbonyloctyl glycosides. The 6-O-substitution tolerated by the enzyme include an alpha-L-fucopyranosyl group and the methyl ester of alpha-linked N-acetylneuraminic acid, but not the free acid itself. The product trisaccharides were characterized by 1H-n.m.r. spectroscopy and fast-atom-bombardment mass spectrometry.

  DOI：

  10.1016/s0008-6215(00)90224-6