{13-[2-Hydroxy-eth-(E)-ylidene]-5-methoxy-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-1-yl}-carbamic acid methyl ester | 212895-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: {13-[2-Hydroxy-eth-(E)-ylidene]-5-methoxy-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-1-yl}-carbamic acid methyl ester
• CAS: 212895-62-0
• 化学式: C₁₈H₂₂N₂O₄
• 分子量: 330.384
• InChiKey: XLYWVXZUEJLRRV-AWNIVKPZSA-N

反应信息

• 作为反应物：
  描述：

  {13-[2-Hydroxy-eth-(E)-ylidene]-5-methoxy-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-1-yl}-carbamic acid methyl ester 在 二乙胺基三氟化硫 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到{13-[2-Fluoro-eth-(E)-ylidene]-5-methoxy-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-1-yl}-carbamic acid methyl ester
  参考文献：
  名称：

  Synthesis and acetylcholinesterase inhibitory activity of (±)-14-fluorohuperzine A

  摘要：

  The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured.Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (-)-huperzine A. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00280-7
• 作为产物：
  描述：

  [5-Methoxy-1-methoxycarbonylamino-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-(13E)-ylidene]-acetic acid ethyl ester 在 二异丁基氢化铝 作用下， 以 四氢呋喃 为溶剂， 以78%的产率得到{13-[2-Hydroxy-eth-(E)-ylidene]-5-methoxy-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5,10-tetraen-1-yl}-carbamic acid methyl ester
  参考文献：
  名称：

  Synthesis and acetylcholinesterase inhibitory activity of (±)-14-fluorohuperzine A

  摘要：

  The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured.Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (-)-huperzine A. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00280-7