Ethyl 3-(2-carbamoylphenyl)prop-2-enoate | 1171010-27-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Ethyl 3-(2-carbamoylphenyl)prop-2-enoate
• 英文别名: ethyl 3-(2-carbamoylphenyl)prop-2-enoate
• CAS: 1171010-27-7
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: AIULGDLIIPITPJ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  硝基甲烷 、 Ethyl 3-(2-carbamoylphenyl)prop-2-enoate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成
  参考文献：
  名称：

  Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks

  摘要：

  Novel imidazole frameworks have been identified as potent partial agonists of the alpha(1A) adrenergic receptor, with good selectivity over the alpha(1B), alpha(1D) and alpha(2A) receptor sub-types. Nitrile 28 possessed attractive CNS drug-like properties with good membrane permeability and no P-pg mediated efflux. 28 also possessed excellent solubility, metabolic stability and wide ligand selectivity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.162