4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]benzaldehyde | 1123622-35-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]benzaldehyde
• CAS: 1123622-35-4
• 化学式: C₂₁H₁₈O₅
• 分子量: 350.371
• InChiKey: HKGCJIAUSDNVOE-KZZDLZNXSA-N

物化性质

• 熔点：
  209-211 °C
• 沸点：
  590.7±50.0 °C(predicted)
• 密度：
  1.264±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]benzaldehyde 在 一水合肼 、 溶剂黄146 作用下， 反应 2.0h， 以51%的产率得到
  参考文献：
  名称：

  Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: Effect on matrix metalloproteinases

  摘要：

  Seven N-unsubstituted curcuminoid pyrazoles have been synthesized from the corresponding beta-diketones ( including curcumin). We evaluated the possibility of curcuminoid pyrazoles regulating the activity of matrix metalloproteinases ( MMPs) by human intestinal epithelial cells in vitro. Zymographic analysis revealed that three compounds significantly down-regulated MMP-9 activity on inflammation-induced intestinal epithelial cells, making them original candidates for the treatment of inflammatory bowel disease (IBD). (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.12.029
• 作为产物：
  描述：

  (5E)-6-(4-羟基-3-甲氧基苯基)-5-己烯-2,4-二酮 、 对苯二甲醛 在 boron trioxide 、 硼酸三丁酯 、 正丁胺 、 盐酸 作用下， 以 N,N-二甲基甲酰胺 、 水 、 乙酸乙酯 为溶剂， 反应 2.0h， 以52%的产率得到4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]benzaldehyde
  参考文献：
  名称：

  Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: Effect on matrix metalloproteinases

  摘要：

  Seven N-unsubstituted curcuminoid pyrazoles have been synthesized from the corresponding beta-diketones ( including curcumin). We evaluated the possibility of curcuminoid pyrazoles regulating the activity of matrix metalloproteinases ( MMPs) by human intestinal epithelial cells in vitro. Zymographic analysis revealed that three compounds significantly down-regulated MMP-9 activity on inflammation-induced intestinal epithelial cells, making them original candidates for the treatment of inflammatory bowel disease (IBD). (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.12.029