| 1175534-10-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• CAS: 1175534-10-7
• 化学式: C₂₀H₁₈BrNO₉
• 分子量: 496.268
• InChiKey: YSTPDXRYFNUGTR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 aluminum tri-bromide 、 盐酸 作用下， 以 乙腈 、 水 为溶剂， 反应 0.33h， 以64%的产率得到3-Bromo-5-hydroxy-6,7,8-trimethoxy-2-(4-methoxy-3-nitrophenyl)chromen-4-one
  参考文献：
  名称：

  Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones

  摘要：

  A series of 3 '-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.008
• 作为产物：
  描述：

  C₂₁H₂₂BrNO₁₀ 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones

  摘要：

  A series of 3 '-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.008