7-chloro-1,4-dimethyl-2-phenyl-4H-imidazo[4,5-d]imidazo[5,4-b]-pyridine | 1134816-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-chloro-1,4-dimethyl-2-phenyl-4H-imidazo[4,5-d]imidazo[5,4-b]-pyridine
• CAS: 1134816-41-3
• 化学式: C₁₅H₁₂ClN₅
• 分子量: 297.747
• InChiKey: YAOBPKAIGNSVLX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  7-chloro-1,4-dimethyl-2-phenyl-4H-imidazo[4,5-d]imidazo[5,4-b]-pyridine 、 盐酸甲胺 在 N,N-二异丙基乙胺 作用下， 以 正丁醇 为溶剂， 反应 4.0h， 以18%的产率得到1,4-dimethyl-7-methylamino-2-phenyl-4H-imidazo[4,5-d]imidazo[5,4-b]pyridine
  参考文献：
  名称：

  Novel Tricyclic Inhibitors of IκB Kinase

  摘要：

  The design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I kappa B kinase (IKK) are reported. Biological activity was improved compared to the pyrazolopurine lead, and the expedient synthesis of the new tricyclic systems allowed for efficient exploration of structure-activity relationships. This, combined with an iterative rat cassette dosing strategy, was used to identify compounds with improved pharmacokinetic (PK) profiles to advance for in vivo evaluation.

  DOI：

  10.1021/jm8015816
• 作为产物：
  描述：

  N-(4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridin-7-yl)-N'-methylbenzamidine 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以67%的产率得到7-chloro-1,4-dimethyl-2-phenyl-4H-imidazo[4,5-d]imidazo[5,4-b]-pyridine
  参考文献：
  名称：

  Novel Tricyclic Inhibitors of IκB Kinase

  摘要：

  The design and synthesis of a novel series of oxazole-, thiazole-, and imidazole-based inhibitors of I kappa B kinase (IKK) are reported. Biological activity was improved compared to the pyrazolopurine lead, and the expedient synthesis of the new tricyclic systems allowed for efficient exploration of structure-activity relationships. This, combined with an iterative rat cassette dosing strategy, was used to identify compounds with improved pharmacokinetic (PK) profiles to advance for in vivo evaluation.

  DOI：

  10.1021/jm8015816