2-(4-chloro-1-methyl-1H-indol-3-yl)-1-phenylethanone | 1334404-92-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-chloro-1-methyl-1H-indol-3-yl)-1-phenylethanone
• CAS: 1334404-92-0
• 化学式: C₁₇H₁₄ClNO
• 分子量: 283.757
• InChiKey: UKVDZGAQLZGYGZ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 scandium tris(trifluoromethanesulfonate) 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 2-(6-chloro-1-methyl-1H-indol-3-yl)-1-phenylethanone 、 2-(4-chloro-1-methyl-1H-indol-3-yl)-1-phenylethanone
  参考文献：
  名称：

  Sc(OTf)₃-Catalyzed Synthesis of Indoles and SnCl₄-Mediated Regioselective Hydrochlorination of 5-(Arylamino)pent-3-yn-2-ones

  摘要：

  Highly substituted indole derivatives bearing alkyl and aryl moieties can be prepared by Sc(OTf)(3)-catalyzed Friedel-Crafts alkenylation of 5-(arylamino)pent-3-yn-2-ones. In addition, a method for regioselective hydrochlorination of 5-(arylamino)pent-3-yn-2-ones mediated by SnCl4 in moderate to good yields (up to 84%) has been developed. The resulting exclusive Z-selectivity of the C-Cl bond can be further exploited using cross C-N coupling reactions.

  DOI：

  10.1021/jo201514q