| 1259026-64-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1259026-64-6
• 化学式: C₂₀H₁₆F₂O₂
• 分子量: 326.343
• InChiKey: ANUIITZCDKFCOP-UHFFFAOYSA-N

物化性质

• 沸点：
  469.7±45.0 °C(predicted)
• 密度：
  1.26±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 iron(III) chloride 、 三甲基氯硅烷 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以73%的产率得到12-(2-chloroethyl)-8,9-difluoro-5-methyl-5H-naphtho[1,2-c]chromene
  参考文献：
  名称：

  Iron-Mediated [3 + 2] or [3 + 3] Annulation of 2-(2-(Ethynyl)phenoxy)-1-arylethanones: Selective Synthesis of Indeno[1,2-c]chromenes and 5H-Naphtho[1,2-c]chromenes

  摘要：

  An iron-mediated tandem annulation strategy has been developed for the synthesis of numerous functional indeno[1,2-c]chromenes and 5H-naphtho[1,2-c]chromenes. This work is the first to disclose an iron-mediated method through sequential electrophilic addition of a ketone to an alkyne and annulation tandem reaction. Importantly, a halide is introduced into the products by a ring-opening process among the annulation of alkynylcyclopropanes, which makes the methodology more attractive for organic synthesis.

  DOI：

  10.1021/ol102761m