| 1610807-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1610807-02-7
• 化学式: C₁₆H₁₁ClN₂O
• 分子量: 282.729
• InChiKey: JIHGJIKUUWTENA-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 邻苯二胺 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  One-Pot Synthesis of Novel Quinoline-Fused Azeto[1,2-a]benzimidazole Analogs Via Intramolecular Pd-Catalyzed C–N Coupling

  摘要：

  A common strategy to incorporate four-membered ring system between benzimidazole and quinoline cores was developed by one-pot protocol involving the condensation of o-phenylenediamine with 2-chloroquinoline-3-carbaldehyde derivatives followed by intramolecular palladium catalyzed C-N coupling. A series of ligands, palladium sources, bases and solvents were screened to optimize the reaction conditions for the synthesis of quinoline-fused azeto[1,2-a]benzimidazoles.An efficient catalytic system for the introduction of 4-membered-ring system between benzimidazole and quinoline cores has been developed by one-pot intramolecular C-N coupling of o-phenylenediamine with 6-substituted-2-chloroquinoline-3-carbaldehydes.

  DOI：

  10.1007/s10562-014-1266-9