| 1609558-93-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1609558-93-1
• 化学式: C₁₃H₁₄N₂O₄
• 分子量: 262.265
• InChiKey: VJOATBKUEDNRDP-UHFFFAOYSA-N

物化性质

• 沸点：
  405.4±45.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  在 lithium chloride 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 2-Cyano-3-pyridylacetat
  参考文献：
  名称：

  A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

  摘要：

  A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyanopyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of primary-amino-substituted 7-azaquinoxaline was also described.

  DOI：

  10.1055/s-0033-1340111
• 作为产物：
  描述：

  丙二酸二乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.17h， 生成
  参考文献：
  名称：

  A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

  摘要：

  A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyanopyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of primary-amino-substituted 7-azaquinoxaline was also described.

  DOI：

  10.1055/s-0033-1340111