4-methoxyphenyl (2,3-di-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->2)-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside | 1192360-97-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxyphenyl (2,3-di-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->2)-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside
• CAS: 1192360-97-6
• 化学式: C₉₁H₁₀₀O₂₁
• 分子量: 1529.78
• InChiKey: KWQPVGXYBRKASJ-PBIWMDEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.37
• 重原子数：
  112.0
• 可旋转键数：
  36.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  209.51
• 氢给体数：
  0.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  4-methoxyphenyl (2,3-di-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->2)-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside 在 甲醇 、 sodium methylate 、 Amberlite IR-120 (H⁺) 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Total synthesis of the heptasaccharide repeating unit of the iron-binding exopolysaccharide secreted by Klebsiella oxytoca BAS-10

  摘要：

  The first total synthesis of a heptasaccharide found in the iron-binding exopolysaccharide produced by Klebsiella oxytoca BAS-10 has been achieved in excellent yield using a block synthetic strategy. A trisaccharide glycosyl donor was stereoselectively coupled with a tetrasaccharide glycosyl acceptor using the trichloroacetimidate activation procedure. The yields and stereo outcome were excellent in each step of glycosylation. A late stage oxidation protocol was adopted for the oxidation of the primary hydroxyl group to the carboxylic functionality while keeping a secondary hydroxyl group unaffected. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.009
• 作为产物：
  描述：

  4-methoxyphenyl (3,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside 、 ethyl 2,3-di-O-acetyl-4-O-benzyl-1-thio-α-L-rhamnopyranoside 在 N-碘代丁二酰亚胺 、 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以85%的产率得到4-methoxyphenyl (2,3-di-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->2)-(3,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-(2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside
  参考文献：
  名称：

  Total synthesis of the heptasaccharide repeating unit of the iron-binding exopolysaccharide secreted by Klebsiella oxytoca BAS-10

  摘要：

  The first total synthesis of a heptasaccharide found in the iron-binding exopolysaccharide produced by Klebsiella oxytoca BAS-10 has been achieved in excellent yield using a block synthetic strategy. A trisaccharide glycosyl donor was stereoselectively coupled with a tetrasaccharide glycosyl acceptor using the trichloroacetimidate activation procedure. The yields and stereo outcome were excellent in each step of glycosylation. A late stage oxidation protocol was adopted for the oxidation of the primary hydroxyl group to the carboxylic functionality while keeping a secondary hydroxyl group unaffected. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.009