| 1160927-41-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• CAS: 1160927-41-2
• 化学式: C₃₅H₇₀N₂₀O₈
• 分子量: 899.07
• InChiKey: BAFGRPJNEIYINK-SDHOMARFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.4
• 重原子数：
  63.0
• 可旋转键数：
  33.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  484.18
• 氢给体数：
  17.0
• 氢受体数：
  14.0

反应信息

• 作为产物：
  描述：

  Boc-beta-丙氨酸 、 、 乙酸酐 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 吡啶 、 乙酸酐 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

  摘要：

  Based on a split-and-mix strategy, a library of trimeric Polyamide Amino Acids (PAA) incorporating four different amino acids (Lys, Ala, Arg, and Phe) has been prepared. Screening of the batches for HIV TAR RNA binding in a fluorescent assay allowed the identification of several components that interact with TAR RNA at a micromolar concentration, with a good TAR versus tRNA specificity. Some of these compounds compete efficiently with the association of TAR and Tat protein. In cell cultures, these compounds display a moderate antiviral activity, associated nevertheless with some toxicity. Overall, these results confirm that this new family can be a basis for the design of novel RNA targeting drugs. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.09.002

文献信息

• Polyamide amino acids: a new class of RNA ligands
  作者：Vanessa Bonnard、Stéphane Azoulay、Audrey Di Giorgio、Nadia Patino

  DOI：10.1039/b815324h

  日期：——

  This communication introduces a new class of promising RNAligands, named polyamideamino acids (PAA), which are able to bind a targeted bulged stem-loopRNA fragment (HIV-1 TAR RNA) with micromolar affinities and with specificity comparative to dsDNA and tRNA; both the affinity and the specificity of PAA for TAR depend on their length and on the nature of the amino acid residues.

  本篇通讯介绍了一类新型有潜力的RNA配体，称为聚酰胺氨基酸（PAA），能够以微摩尔亲和力结合靶向的茎环RNA片段（HIV-1 TAR RNA），并且具有与双链DNA和tRNA可比的特异性；PAA对TAR的亲和力和特异性取决于它们的长度和氨基酸残基的性质。