O-hexadecyl-hydroxylamine; hydrochloride | 38936-50-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-hexadecyl-hydroxylamine; hydrochloride
• 英文别名: O-hexadecylhydroxylamine;hydrochloride
• CAS: 38936-50-4
• 化学式: C₁₆H₃₅NO*ClH
• 分子量: 293.921
• InChiKey: KFNDQQOROASPIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  19.0
• 可旋转键数：
  15.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.25
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  二聚氰胺 、 O-hexadecyl-hydroxylamine; hydrochloride 以 乙醇 为溶剂， 生成 Hexadecyloxy-diguanid
  参考文献：
  名称：

  45.氨基氧基衍生物。第二部分 N-羟基二胍的一些衍生物

  摘要：

  DOI：

  10.1039/jr9600000229
• 作为产物：
  描述：

  1-Aminooxy-hexadecan 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 O-hexadecyl-hydroxylamine; hydrochloride
  参考文献：
  名称：

  Synthesis and Fungicidal Activity of Macrolactams and Macrolactones with an Oxime Ether Side Chain

  摘要：

  Three series of novel macrolactams and macrolactones - 12-alkoxyimino-tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by H-1 NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by H-1 NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuhn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.

  DOI：

  10.1021/jf072733+