1-(2-t-butyl-6-(isobutyryl)phenyl)-1-methyl-3-phenylurea | 1017952-65-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-t-butyl-6-(isobutyryl)phenyl)-1-methyl-3-phenylurea
• CAS: 1017952-65-6
• 化学式: C₂₂H₂₈N₂O₂
• 分子量: 352.477
• InChiKey: GHSSVTMQSIYGOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.49
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.41
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-(2-t-butyl-6-(isobutyryl)phenyl)-1-methyl-3-phenylurea 在 sodium tetrahydroborate 作用下， 以100%的产率得到1-(2-叔丁基-6-(1-羟基-2-甲基丙基)苯基)-1-甲基-3-苯基脲
  参考文献：
  名称：

  N,N′-Diarylureas: A New Family of Atropisomers Exhibiting Highly Diastereoselective Reactivity

  摘要：

  2,6-Disubstituted N-aryl ureas rotate slowly about their Ar-N bonds and can exist as separable atropisomers. They also react remarkably diastereoselectively, with the urea axis controlling new stereogenic centers with high fidelity in a variety of nucleophilic and electrophilic addition reactions. The sense of diastereoselectivity in lateral lithiation-electrophilic quench reactions is electrophile-dependent and appears to be the result of stereospecific reaction with one of two interconvertible diastereoisomeric organolithiums.

  DOI：

  10.1021/jo702706c
• 作为产物：
  描述：

  1-(2-叔丁基-6-(1-羟基-2-甲基丙基)苯基)-1-甲基-3-苯基脲 在 jones' reagent 作用下， 以 丙酮 为溶剂， 以100%的产率得到1-(2-t-butyl-6-(isobutyryl)phenyl)-1-methyl-3-phenylurea
  参考文献：
  名称：

  N,N′-Diarylureas: A New Family of Atropisomers Exhibiting Highly Diastereoselective Reactivity

  摘要：

  2,6-Disubstituted N-aryl ureas rotate slowly about their Ar-N bonds and can exist as separable atropisomers. They also react remarkably diastereoselectively, with the urea axis controlling new stereogenic centers with high fidelity in a variety of nucleophilic and electrophilic addition reactions. The sense of diastereoselectivity in lateral lithiation-electrophilic quench reactions is electrophile-dependent and appears to be the result of stereospecific reaction with one of two interconvertible diastereoisomeric organolithiums.

  DOI：

  10.1021/jo702706c