(2-methyl-3-butenyl)magnesium bromide | 115143-22-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-methyl-3-butenyl)magnesium bromide
• 英文别名: 2-methyl-3-butylmagnesium bromide
• CAS: 115143-22-1
• 化学式: C₅H₉BrMg
• 分子量: 173.335
• InChiKey: UFHFPSVGALMDTO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  7.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  (2-methyl-3-butenyl)magnesium bromide 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 144.0h， 生成 2-(2-methyl-3-butenyl)-2-<1(S)-phthalimido-2-phenylethyl>-1,3-dioxolane
  参考文献：
  名称：

  二肽酮亚甲基类似物的合成

  摘要：

  描述了一种通过使用均等的格氏试剂作为氨基酸类似物合成子来合成酮亚甲基二肽的简便方法。

  DOI：

  10.1016/s0040-4039(00)87388-8

文献信息

• Metal promoted cyclization. 18. Novel cyclialkylation reactions of (.omega.-halo-1-alkenyl)metal derivatives. Synthetic scope and mechanism
  作者：Eiichi. Negishi、Larry D. Boardman、Hiroyuki. Sawada、Vahid. Bagheri、A. Timothy. Stoll、James M. Tour、Cynthia L. Rand

  DOI：10.1021/ja00224a025

  日期：1988.8

  Cyclisation d'(ω-halogenoalcene-1yl) M et d'([ω-halogeno trimethylsilyl-1] alcene-1yl) M en cyclenes (M=aluminium, zinc, zirconium, ou silicium)

  环化 d'(ω-halogenoalcene-1yl) M et d'([ω-halogeno trimethylsilyl-1] alcene-1yl) M 环烯（M = 铝、锌、锆、硅）
• A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes: facile synthesis of ent-kaurene and cedrene-type skeletons
  作者：Chi He、Zengbing Bai、Jialei Hu、Bingnan Wang、Hujun Xie、Lei Yu、Hanfeng Ding

  DOI：10.1039/c7cc04292b

  日期：——

  A solvent-dependent oxidative dearomatization-induced divergent [5+2] cascade approach to bicyclo[3.2.1]octanes was described. This novel protocol enables a facile synthesis of a series of diversely functionalized ent-kaurene and cedrene-type skeletons in good yields and excellent diastereoselectivities.

  描述了溶剂依赖性的氧化脱芳香化作用诱导的发散[5 + 2]级联方法生成双环[3.2.1]辛烷。这种新颖的协议使得一系列不同地官能化的的简便合成ENT以良好的收率和优良的非对映选择性和-kaurene雪松烯型骨架。
• Derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: effect of changes at postions 2 and 5 of the hexanoic acid portion
  作者：Ronald G. Almquist、Jac Crase、Clive Jennings-White、Robert F. Meyer、Milton L. Hoefle、Ronald D. Smith、Arnold D. Essenburg、Harvey R. Kaplan

  DOI：10.1021/jm00353a005

  日期：1982.11

  Several derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline (1) were synthesized and tested for converting enzyme inhibition activity and blood pressure lowering effects in rats. One compound, 5(S)-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline (2a), had and I50 against angiotensin converting enzyme of 1.0 x 10(-9) M and is the most potent inhibitor prepared thus far in this class of compounds. Testing of 2a orally at 30 mg/kg for inhibition of the angiotensin I induced blood pressure increase in conscious normotensive rats gave 100% inhibition that required 143 min before the angiotensin I blood pressure response returned to 70% of the pretreatment control response. In the conscious renal hypertensive rat, 2a given orally at a dose of 3 mg/kg caused a lowering of blood pressure that reached its maximum of 40 mmHg 8 h following drug administration.
• Metal promoted cyclization. 5. Mechanistic duality in cyclialkylation of alkenylmetal derivatives
  作者：Larry D. Boardman、Vahid Bagheri、Hiroyuki Sawada、Eiichi Negishi

  DOI：10.1021/ja00332a072

  日期：1984.10