<2R,3R,4S,5R>-3,4-Dihydroxy-2-hydroxymethyl-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione | 130607-18-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <2R,3R,4S,5R>-3,4-Dihydroxy-2-hydroxymethyl-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione
• 英文别名: (5R,7R,8R,9S)-8,9-dihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.4]nonane-2,4-dione
• CAS: 130607-18-0
• 化学式: C₇H₁₀N₂O₆
• 分子量: 218.166
• InChiKey: RFZZKBWDDKMWNM-BMOCKJADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (5R,7R,8R,9S)-7-Benzyloxymethyl-8,9-dihydroxy-6-oxa-1,3-diaza-spiro[4.4]nonane-2,4-dione 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 <2R,3R,4S,5R>-3,4-Dihydroxy-2-hydroxymethyl-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione
  参考文献：
  名称：

  Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin

  摘要：

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.

  DOI：

  10.1016/s0040-4020(01)96123-x

文献信息

• Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin
  作者：Shigeru Mio、Mikiko Shiraishi、Soji Sugai、Hideyuki Haruyama、Sadao Sato

  DOI：10.1016/s0040-4020(01)96123-x

  日期：——

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.