tetradeca-1,13-diene-3,12-dione | 588707-96-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tetradeca-1,13-diene-3,12-dione
• CAS: 588707-96-4
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: IDKKAMDKZZSADC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tetradeca-1,13-diene-3,12-dione 、 3-(4-[tris(4-tert-butylphenyl)methyl]phenoxy)propyl 2-cyanopropanoate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 168.0h， 以74%的产率得到
  参考文献：
  名称：

  通过四组分Pd（II）促进的迈克尔加成反应，动态切换轮烷和分子穿梭物的活性模板。

  摘要：

  DOI：

  10.1002/anie.200705859
• 作为产物：
  描述：

  vinylmagnesium bromide 、 N-methoxy-10-(methoxy(methyl)amino)-N-methyl-10-oxoundecanamide 以 四氢呋喃 为溶剂， 以75%的产率得到tetradeca-1,13-diene-3,12-dione
  参考文献：
  名称：

  通过四组分Pd（II）促进的迈克尔加成反应，动态切换轮烷和分子穿梭物的活性模板。

  摘要：

  DOI：

  10.1002/anie.200705859

文献信息

• NANOCOMPOSITES OF GOLD AND POLYMERS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20140294909A1

  公开（公告）日：2014-10-02

  A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.

  本文介绍了一种逐层（LbL）系统，该系统交替离子复合两种独特的阳离子聚合物（二硫键可还原和水解降解）和两种阴离子核酸到阴离子AuNPs上。
• A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES
  申请人：The Johns Hopkins University

  公开号：EP3003343B1

  公开（公告）日：2019-10-23
• PEPTIDE/PARTICLE DELIVERY SYSTEMS
  申请人：Green Jordan Jamieson

  公开号：US20120114759A1

  公开（公告）日：2012-05-10

  Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
• Multicomponent Degradable Cationic Polymers
  申请人：Green Jordan J.

  公开号：US20120128782A1

  公开（公告）日：2012-05-24

  Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000 ™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
• POLY(BETA-AMINO ESTER)-CO-POLYETHYLENE GLYCOL (PEG-PBAE-PEG) POLYMERS FOR GENE AND DRUG DELIVERY
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20180112038A1

  公开（公告）日：2018-04-26

  Polyethylene glycol (PEG)-b-poly(β-amino ester) (PBAE) co-polymers (PEG-PBAE) and blends of PEG-PBAEs and PBAEs and their use for delivering drugs, genes, and other pharmaceutical or therapeutic agents safely and effectively to different sites in the body and to different cells, such as cancer cells, are disclosed.