(1S,5S,6R,10S,11R,15R,16S,20R,21R,22S,23S,24R)-8,8,18,18-tetramethyl-3,13-bis[2-tri(propan-2-yl)silylethynyl]-7,9,17,19-tetraoxaheptacyclo[13.5.2.25,11.02,14.04,12.06,10.016,20]tetracosa-2(14),3,12-triene-21,22,23,24-tetrol | 1239898-63-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,5S,6R,10S,11R,15R,16S,20R,21R,22S,23S,24R)-8,8,18,18-tetramethyl-3,13-bis[2-tri(propan-2-yl)silylethynyl]-7,9,17,19-tetraoxaheptacyclo[13.5.2.25,11.02,14.04,12.06,10.016,20]tetracosa-2(14),3,12-triene-21,22,23,24-tetrol
• CAS: 1239898-63-5
• 化学式: C₄₆H₇₀O₈Si₂
• 分子量: 807.228
• InChiKey: APNLINHHPGWZKH-VGTPBRNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  56
• 可旋转键数：
  10
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (1S,5S,6R,10S,11R,15R,16S,20R,21R,22S,23S,24R)-8,8,18,18-tetramethyl-3,13-bis[2-tri(propan-2-yl)silylethynyl]-7,9,17,19-tetraoxaheptacyclo[13.5.2.25,11.02,14.04,12.06,10.016,20]tetracosa-2(14),3,12-triene-21,22,23,24-tetrol 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到
  参考文献：
  名称：

  Rigid Hydrophilic Structures for Improved Properties of Conjugated Polymers and Nitrotyrosine Sensing in Water

  摘要：

  The efficient synthesis of a hydrophilic monomer bearing a three-dimensional noncompliant array of hydroxyl groups is described that prevents water-driven excimer features of hydrophobic poly(p-phenylene ethynylene) backbones. Sensitivity of the polymer to 3-nitrotyrosine is also discussed.

  DOI：

  10.1021/ol1001768
• 作为产物：
  描述：

  在 三乙烯二胺 、 potassium osmate(VI) dihydrate 、 甲基磺酰胺 、 potassium carbonate 、 potassium hexacyanoferrate(III) 作用下， 以 水 、 叔丁醇 为溶剂， 反应 24.0h， 以57%的产率得到(1S,5S,6R,10S,11R,15R,16S,20R,21R,22S,23S,24R)-8,8,18,18-tetramethyl-3,13-bis[2-tri(propan-2-yl)silylethynyl]-7,9,17,19-tetraoxaheptacyclo[13.5.2.25,11.02,14.04,12.06,10.016,20]tetracosa-2(14),3,12-triene-21,22,23,24-tetrol
  参考文献：
  名称：

  Rigid Hydrophilic Structures for Improved Properties of Conjugated Polymers and Nitrotyrosine Sensing in Water

  摘要：

  The efficient synthesis of a hydrophilic monomer bearing a three-dimensional noncompliant array of hydroxyl groups is described that prevents water-driven excimer features of hydrophobic poly(p-phenylene ethynylene) backbones. Sensitivity of the polymer to 3-nitrotyrosine is also discussed.

  DOI：

  10.1021/ol1001768

文献信息

• Biocompatible post-polymerization functionalization of a water soluble poly(p-phenylene ethynylene)
  作者：Brett VanVeller、Timothy M. Swager

  DOI：10.1039/c0cc01456g

  日期：——

  A biocompatible post-polymerization functionalization reaction takes advantage of a polymer's structural motif for the controllable attachment of biotin as a model biosensor that responds to streptavidin.

  生物相容性聚合后功能化反应利用了聚合物的结构基序，可控制地附着生物素，作为对链霉亲和素有反应的模型生物传感器。