2-环己基-2-甲基-1-丙醇 | 62435-08-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-环己基-2-甲基-1-丙醇
• 英文名称: 2-cyclohexyl-2-methylpropanol
• 英文别名: 2-Cyclohexyl-2-methylpropan-1-ol
• CAS: 62435-08-9
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: HLVYTWAZPRTCMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-环己基-2-甲基-1-丙醇 、 草酰氯 以 二甲基亚砜 为溶剂， 生成 α-Cyclohexyl-i-butyraldehyd
  参考文献：
  名称：

  Aminal diones as potassium channel openers

  摘要：

  式(I)的化合物可能在治疗由钾通道开放剂预防或改善的疾病中有用。还披露了开放钾通道的组合物和在哺乳动物中开放钾通道的方法。

  公开号：

  US06495576B2

文献信息

• Potassium channel openers
  申请人：——

  公开号：US20020028836A1

  公开（公告）日：2002-03-07

  Compounds of formula I: 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  公式I的化合物： 1 在治疗通过或用钾通道开放剂预防或改善的疾病中是有用的。还公开了钾通道开放组合物以及在哺乳动物中开放钾通道的方法。
• Aminal Diones as potassium channel openers
  申请人：——

  公开号：US20020147230A1

  公开（公告）日：2002-10-10

  Compounds of formula (I) 1 may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  化合物的化学式（I）可能在治疗由钾通道开放剂预防或改善的疾病中有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
• Substituted 1,3-benzodioxoles
  申请人：American Home Products Corporation

  公开号：US05914339A1

  公开（公告）日：1999-06-22

  The present invention provides new compounds having anti-diabetic and/or antihyperglycemia and/or anti-obesity activity, as well as pharmaceutical compositions and methods of treatment utilizing the compounds and processes for making the compounds, the compounds having the formula (II): ##STR1## wherein: R.sub.1 and R.sub.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen; R.sub.2 is hydrogen or C.sub.1 to C.sub.6 trialkylsilyl; R.sub.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl; or R.sub.2 and R.sub.3 are joined to form a ring: ##STR2## wherein R' is hydrogen, C.sub.1 to C.sub.6 alkyl, or aryl; R.sub.4 and R.sub.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl; R.sub.7 and R.sub.8 are independently OR.sub.9 or NR.sub.10 R.sub.11 ; R.sub.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 cycloalkyl, C.sub.1 to C.sub.12 silylalkyl, aryl, arylalkyl, alkoxyalkyl, heteroaryl, --CHR.sub.12 COOR.sub.13, --CHR.sub.12 C(O)R.sub.13, --CHR.sub.12 CONR.sub.1 R.sub.11, --CHR.sub.12 OCOOR.sub.13, or --CHR.sub.12 OC(O)R.sub.13, with the provision that R.sub.9 is not hydrogen in both R.sub.7 and R.sub.8 ; R.sub.10 and R.sub.11 are independently hydrogen, C.sub.1 to C.sub.12 alkyl, aralkyl, aryl, furanylalkyl, or alkoxycarbonylalkyl; R.sub.12 and R.sub.13 are independently hydrogen, C.sub.1 to C.sub.12 alkyl, aryl, or aralkyl; and the pharmaceutically acceptable salts thereof, the enantiomers thereof, the racemic mixtures thereof, and the diastereomeric mixtures thereof.

  该发明提供了具有抗糖尿病和/或抗高血糖和/或抗肥胖活性的新化合物，以及利用该化合物的制药组合物和治疗方法以及制备该化合物的方法，该化合物具有以下式子（II）： ##STR1## 其中：R.sub.1和R.sub.6独立地为氢、C.sub.1到C.sub.6烷基、三氟甲基、氰基、C.sub.1到C.sub.6烷氧基或卤素；R.sub.2为氢或C.sub.1到C.sub.6三烷基硅基；R.sub.3为氢或C.sub.1到C.sub.6烷氧羰基；或者R.sub.2和R.sub.3连接形成环： ##STR2## 其中R'为氢、C.sub.1到C.sub.6烷基或芳基；R.sub.4和R.sub.5独立地为氢或C.sub.1到C.sub.6烷基；R.sub.7和R.sub.8独立地为OR.sub.9或NR.sub.10R.sub.11；R.sub.9为氢、C.sub.1到C.sub.12烷基、C.sub.1到C.sub.12环烷基、C.sub.1到C.sub.12硅基烷基、芳基、芳基烷基、烷氧基烷基、杂环芳基、--CHR.sub.12COOR.sub.13、--CHR.sub.12C（O）R.sub.13、--CHR.sub.12CONR.sub.1R.sub.11、--CHR.sub.12OCOOR.sub.13或--CHR.sub.12OC（O）R.sub.13，但R.sub.9在R.sub.7和R.sub.8中不同时为氢；R.sub.10和R.sub.11独立地为氢、C.sub.1到C.sub.12烷基、芳基烷基、芳基、呋喃基烷基或烷氧羰基烷基；R.sub.12和R.sub.13独立地为氢、C.sub.1到C.sub.12烷基、芳基或芳基烷基；以及其药学上可接受的盐、对映体、混合物和非对映异构体混合物。
• SUBSTITUTED 1, 3-BENZODIOXOLES
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0901484A1

  公开（公告）日：1999-03-17
• ESTERS WITH MUSKY ODOR AND THEIR USE IN PERFUMERY
  申请人：FIRMENICH SA

  公开号：EP1047660A1

  公开（公告）日：2000-11-02