Bis-<4-(4-hydroxy-butyloxy)-butyl>-aether | 61136-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bis-<4-(4-hydroxy-butyloxy)-butyl>-aether
• 英文别名: tetrabutylene glycol；1,19-dihydroxy-5,10,15-trioxanonadecane；1-Butanol, 4,4'-[oxybis(4,1-butanediyloxy)]bis-；4-[4-[4-(4-hydroxybutoxy)butoxy]butoxy]butan-1-ol
• CAS: 61136-07-0
• 化学式: C₁₆H₃₄O₅
• 分子量: 306.443
• InChiKey: VXJPOBFTRXQDMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Bis-<4-(4-hydroxy-butyloxy)-butyl>-aether 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 tetrabutylene glycol bis-mesylate
  参考文献：
  名称：

  Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

  摘要：

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.016
• 作为产物：
  描述：

  2,2'-(oxybis(propane-3,1-diyl))bis(1,3-dioxepane) 在 硼烷四氢呋喃络合物 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到Bis-<4-(4-hydroxy-butyloxy)-butyl>-aether
  参考文献：
  名称：

  Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

  摘要：

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.016

文献信息

• Manufacture of Esters Using a Multiple Catalyst Approach
  申请人：Hillshafer D. Kip

  公开号：US20080132714A1

  公开（公告）日：2008-06-05

  Esters are prepared from hydroxyl-containing compounds and carboxylic acids or anhydrides or lower alkyl esters thereof using a multiple catalyst approach, wherein a first catalyst such as an organotin catalyst can be present at the beginning of the reaction and a second catalyst such as an organotitanium catalyst can be added any time after the addition of the first catalyst, or when the acid value of the reaction mixture falls below a predetermined acid value. The second catalyst can be added multiple times, and a third or additional catalysts can also be used.

  酯类化合物是通过使用多催化剂方法从含羟基化合物和羧酸或酐或其低烷基酯制备的，其中第一催化剂，如有机锡催化剂，可以在反应开始时存在，第二催化剂，如有机钛催化剂，可以在添加第一催化剂后的任何时间添加，或者当反应混合物的酸值降至预定酸值以下时添加。第二催化剂可以多次添加，并且还可以使用第三或更多的催化剂。
• Verfahren zur Herstellung von kompakten oder zelligen Polyurethan-Elastomeren in Gegenwart eines Titan- und/oder Zinnverbindungen enthaltenden Polyester-polyols als Katalysator sowie die Verwendung dieses Katalysators
  申请人：BASF Aktiengesellschaft

  公开号：EP0269873A2

  公开（公告）日：1988-06-08

  Die Erfindung betrifft ein Verfahren zur Herstellung von kompakten oder zelligen Polyurethan-Elastomeren durch Umsetzung von a) organischen Polyisocyanaten, vorzugsweise in Form von NCO-Gruppen enthaltenden Prepolymeren und/oder modifizierten Urethangruppen enthaltenden organischen Polyisocyanaten mit b) höhermolekularen Verbindungen mit mindestens 2 reaktiven Wasserstoff­atomen, vorzugsweise Polyester- oder Polyether-polyolen und gegebenenfalls c) Kettenverlängerungs- und/oder Vernetzungsmitteln in Gegenwart von d) Katalysatoren und gegebenenfalls e) Treibmitteln, f) Hilfsmitteln und/oder Zusatzstoffen, wobei als Katalysatoren vorteilhafterweise 0,1 bis 10 Gew.-Teile eines Polyester-polyols, bezogen auf 100 Gew.-Teile der Komponente b) verwendet werden, das hergestellt wird durch Polykondensation von organischen Polycarbonsäuren mit mehrwertigen Alkoholen in Gegenwart von 0,002 bis 5 Gew.% mindestens einer Titan- und/oder Zinnverbindung, bezogen auf das Gewicht des Polykondenastionsgemisches, als Katalysator bei Temperaturen von 150 bis 250°C sowie die Verwendung dieses Katalysators zur Herstellung von Kunststoffen nach dem Polyisocyanat-Polyadditionsverfahren, vorzugsweise von Polyurethan-Kunststoffen.

  本发明涉及一种生产紧凑型或蜂窝状聚氨酯弹性体的工艺，该工艺通过以下反应进行生产 a) 有机多异氰酸酯，最好是含有 NCO 基团的预聚物和/或含有聚氨酯基团的改性有机 多异氰酸酯，与 b) 具有至少 2 个活性氢原子的高分子量化合物，最好是聚酯或聚醚多元醇，可选 c) 扩链剂和/或交联剂，并加入 d) 催化剂，可选 e) 发泡剂 f) 辅助剂和/或添加剂、 使用的催化剂最好是 0.1 至 10 重量份的聚酯多元醇（以 100 重量份的 b) 组分为基数），其制备方法是有机聚羧酸与多元醇在 150 至 250°C 的温度下，在至少一种钛和/或锡化合物（以缩聚混合物的重量为基数） 0.002 至 5%（重量百分比）的存在下作为催化剂进行缩聚。 使用该催化剂通过多异氰酸酯加聚工艺生产塑料，最好是聚氨酯塑料。
• Electrophotographic developer composition
  申请人：Kao Corporation

  公开号：EP0320819A2

  公开（公告）日：1989-06-21

  An electrophotographic toner comprises a polyester made from a diol and a dicarboxylic acid, further comprising (a) a diol and (b) a diol and (d) a tribasic or higher carboxylic acid and at least one charge controller. It may further comprise (e) a diol. (a), (b) and (e) are defined by the formulae.

  电子照相调色剂包括由二元醇和二羧酸制成的聚酯，还包括(a)二元醇和(b)二元醇和(d)三元或更高的羧酸以及至少一个电荷控制器。还可进一步包括(e)二元醇。(a)、(b)和(e)由式定义。
• Two-component aqueous polyurethane dispersions
  申请人：MILES INC.

  公开号：EP0469389A1

  公开（公告）日：1992-02-05

  The present invention relates to a two-component, aqueous polyurethane coating composition which may be cured at ambient temperature and which contains I) a first component based on an aqueously dispersed polyurethane wherein the polyurethane has a) an average hydroxy functionality of at least 1.8, b) a total content of urethane and urea groups, calculated as -NH-CO- (molecular weight = 43), of 9 to 20% by weight, based on the weight of the polyurethane, c) sufficient chemically incorporated anionic and d) ethylene oxide units incorporated within terminal and/or lateral polyether chains, to maintain the polyurethane stably dispersed in water, II) a second component based on a water dispersible polyisocyanate wherein the polyisocyanate has a) an isocyanate content of 2 to 30% by weight, based on the weight of the polyisocyanate, b) an average functionality of at least 1.8, c) sufficient chemically incorporated anionic groups and d) ethylene oxide units incorporated within terminal and/or lateral polyether chains, to maintain the polyisocyanate stably dispersed in water, and components I and II are present in an amount sufficient to provide an equivalent ratio of isocyanate groups to hydroxyl groups of 0.8:1 to 6:1, and III) optionally up to 20% by weight, based on the weight of components I and II, of a polyol which has a molecular weight of 62 to 1000 and may contain ether groups. The present invention is also directed to the coatings prepared from these coating compositions.

  本发明涉及一种可在环境温度下固化的双组分水性聚氨酯涂料组合物，该组合物包含 I) 基于水性分散聚氨酯的第一组份，其中聚氨酯具有 a) 平均羟基官能度至少为 1.8、 b) 以聚氨酯重量计算，氨基甲酸酯和脲基的总含量（以-NH-CO-（分子量＝43）计 算）为 9-20%（按重量计）、 c) 充分的化学合成阴离子和 d) 在末端和/或侧面聚醚链中掺入环氧乙烷单元、 以保持聚氨酯在水中的稳定分散、 第二组份基于可在水中分散的多异氰酸酯，其中多异氰酸酯具有以下特性 a) 异氰酸酯含量为 2%至 30%（以多异氰酸酯重量计）、 b) 平均官能度至少为 1.8、 c) 充分的化学合成阴离子基团，以及 d) 末端和/或侧面聚醚链中含有环氧乙烷单元、 组分 I 和组分 II 的存在量足以使异氰酸酯基团与羟基的当量比为 0.8:1 至 6:1，以及 III）以组分 I 和组分 II 的重量为基准，任选不超过 20%（按重量计）的多元醇，其分子量为 62 至 1000，可含有醚基。 本发明还涉及用这些涂料组合物制备的涂料。
• Pour point depressants for high monounsaturated vegetable oils and for high monounsaturated vegetable oils/biodegradable base and fluid mixtures
  申请人：The Lubrizol Corporation

  公开号：EP0604125A1

  公开（公告）日：1994-06-29

  An industrial lubricant composition is described that comprises (A) at least one vegetable or synthetic triglyceride oil of the formula wherein R¹, R² and R³ are aliphatic hydrocarbyl groups having at least 60 percent monounsaturated character and containing from about 6 to about 24 carbon atoms and (B) at least one pour point depressant. Optionally, the composition may also contain (C) a performance additive and (D) an oil.

  所述工业润滑油组合物包括 (A) 至少一种植物或合成甘油三酯油，其式如下 其中 R¹、R² 和 R³ 是脂肪族烃基，具有至少 60% 的单不饱和性质，并含有约 6 至约 24 个碳原子，以及 (B) 至少一种降凝剂。 可选地，组合物还可包含 (C) 性能添加剂和 (D) 一种油。