4-(3-formylphenoxy)butanoic acid | 174884-10-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3-formylphenoxy)butanoic acid
• 英文别名: 4-(3-formyl-phenoxy)-butyric acid
• CAS: 174884-10-7
• 化学式: C₁₁H₁₂O₄
• mdl: MFCD09673366
• 分子量: 208.214
• InChiKey: QHLKXVXBJDXSHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  426.7±25.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[4-(4-methyl-piperazin-1-yl)-4-oxo-butoxy]-benzaldehyde 、 4-(3-formylphenoxy)butanoic acid 、 N-甲基哌嗪 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 1-羟基苯并三唑一水物 在 乙酸乙酯 、 Sodium sulfate-III 、 crude residue 、 silica gel 、 甲醇 、 二氯甲烷 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以to afford 847 mg (62%) of the desired product的产率得到4-[3-(5-tert-butyl-1H-benzoimidazol-2-yl)-phenoxy]-1-(4-methyl-piperazin-1-yl)-butan-1-one
  参考文献：
  名称：

  Benzoimidazole compounds

  摘要：

  苯并咪唑化合物、组合物及其在白细胞招募抑制、调节H4受体和治疗炎症、H4受体介导的疾病及相关疾病方面的应用方法。

  公开号：

  US07432378B2
• 作为产物：
  描述：

  4-(3-甲酰基苯氧基)丁酸乙酯 、 potassium carbonate 在 sodium hydroxide 、 乙醚 、 乙酸乙酯 、 氯化钠 、 magnesium sulfate 作用下， 以 水合甲醇 为溶剂， 反应 8.0h， 以to give 315 mg of 4-(3-formylphenoxy)butanoic acid as a white solid的产率得到4-(3-formylphenoxy)butanoic acid
  参考文献：
  名称：

  Linkers useful for the synthesis of conjugates of methyltrithio

  摘要：

  本发明描述了由强效抗肿瘤抗生素calicheamicin家族的二硫键类似物及其衍生物以及类似的esperamicins的类似物制备的载体-药物共轭物，载体可以是抗体、生长因子或类固醇，其针对不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及它们的抗原识别片段和它们的化学或基因操作的对应物对于共轭物的靶向部分是有用的。本发明包括用于这些共轭物的合成所需的化合物，载体-药物共轭物的适当药物组成以及它们的使用方法。

  公开号：

  US05767285A1

文献信息

• CELL IMPERMEABLE COELENTERAZINE ANALOGUES
  申请人：PROMEGA CORPORATION

  公开号：US20180155350A1

  公开（公告）日：2018-06-07

  Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

  本文描述了水螅素类似物、制备该类似物的方法、包含该类似物的试剂盒以及使用该化合物检测基于荧光素酶的测定中发光的方法。
• Enediyne derivatives useful for the synthesis of conjugates of
  申请人：American Cyanamid Company

  公开号：US05739116A1

  公开（公告）日：1998-04-14

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由卡利切阿霉素家族的二硫键类似物及其衍生物制备的载体-药物共轭物，以及来自相关抗肿瘤抗生素如埃斯佩拉霉素的类似物。载体可以是抗体、生长因子或类固醇，其针对不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及其抗原识别片段及其化学或基因操作的对应物对该共轭物的靶向部分非常有用。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当制药组合物以及它们的使用方法。
• Conjugates of methyltrithio antitumor agents and intermediates for their
  申请人：American Cyanamid Company

  公开号：US05773001A1

  公开（公告）日：1998-06-30

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由卡利奇阿霉素家族的二硫化物类似物及其衍生物制备的载体-药物共轭物，以及来自相关抗肿瘤抗生素（如埃斯佩拉霉素）的类似物。载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，如肿瘤细胞。整个蛋白质载体以及其抗原识别片段和其化学或基因操作的对应物对共轭物的靶向部分都有用。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当药物组成以及它们的使用方法。
• Benzoimidazole Compounds
  申请人：Edwards James P.

  公开号：US20090247508A1

  公开（公告）日：2009-10-01

  Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 receptor-mediated conditions, and related conditions.

  苯并咪唑化合物，组合物，以及它们在白细胞招募抑制，调节H4受体和治疗炎症，H4受体介导的疾病和相关疾病方面的使用方法。
• Process for preparing conjugates of methyltrithio antitumor agents
  申请人：American Cyanamid Company

  公开号：US05877296A1

  公开（公告）日：1999-03-02

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了从卡利切阿霉素家族的二硫化物类似物及其衍生物以及类似的抗肿瘤抗生素如埃斯佩拉霉素中制备的载体-药物结合物，载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及其抗原识别片段以及其化学或基因操纵的对应物对于结合物的靶向部分是有用的。本发明包括合成这些结合物所需的化合物，载体-药物结合物的适当药物组成以及它们的使用方法。