法莫替丁EP杂质A | 124646-10-2

• 物质功能分类: 分析化学 - 对照品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 法莫替丁EP杂质A
• 英文名称: 3-[[2-[(diaminomethylene)amino]thiazol-4yl]methyl]sulphanylpropanimidamide
• 英文别名: 3-((2-(Diaminomethyleneamino)thiazol-4-yl)methylthio)propanimidamide；3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]propanimidamide
• CAS: 124646-10-2
• 化学式: C₈H₁₄N₆S₂
• 分子量: 258.371
• InChiKey: FANULGZDUAVRRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  181
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  法莫替丁EP杂质A 、 乙酰乙酸乙酯 生成 2-[4-[2-(4-methyl-6-oxo-1H-pyrimidin-2-yl)ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine
  参考文献：
  名称：

  YANAGISAVA, ISAO

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(((胍基-4-噻唑基)甲基)硫)丙亚氨酸甲酯 在 氯化铵 作用下， 以 甲醇 为溶剂， 生成 法莫替丁EP杂质A
  参考文献：
  名称：

  NOVEL COMPOUND, ORGANIC CATION TRANSPORTER 3 DETECTION AGENT, AND ORGANIC CATION TRANSPORTER 3 ACTIVITY INHIBITOR

  摘要：

  公开号：

  EP3018125B1

文献信息

• New-quanidino-thiazol compounds, their preparation, and use as intermediates of famotidine process
  申请人：CENTRO MARGA PARA LA INVESTIGACION S.A.

  公开号：EP0322335A1

  公开（公告）日：1989-06-28

  New 2-guanidino-thiazol compounds with the general formulas where R° represents an hydrogen atom or an alkyl group of low molecular weight, m = 2 to 7, n = 2 to 4, and being R an alkyl group of low molecular weight and that may contain from one N-alkylsilyl group, that are important intermediates for the famotidine preparation, medically used as inhibitor of the gastric secretion.

  具有一般公式的新2-胍基噻唑化合物，其中R°代表氢原子或低分子量的烷基基团，m = 2至7，n = 2至4，R是低分子量的烷基基团，可能含有一个N-烷基硅基团，这些化合物是法莫替定制备的重要中间体，医学上用作胃分泌抑制剂。
• IMPURITY OF FAMOTIDINE
  申请人：GAVIS PHARMACEUTICALS

  公开号：US20160376245A1

  公开（公告）日：2016-12-29

  The present invention is directed to a new impurity of famotidine, process for preparing and isolating it. The invention is further related to analytical methods of its identification, synthesis and characterization.

  本发明涉及法莫替丁的一种新杂质，其制备和分离的过程。该发明还涉及其鉴定、合成和表征的分析方法。
• Guanidinothiazole compounds, and medical compositions containing them
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04362736A1

  公开（公告）日：1982-12-07

  Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1-3, A represents the group shown by ##STR2## (wherein R.sub.1 represents a hydrogen atom, a cyano group, a carbamoyl group, a ureido group, a hydroxyl group, a lower alkoxy group, a lower acyl group, an acylamino group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group or a lower acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group or a sulfamoyl group), and the pharmacologically acceptable acid addition salts thereof; these compounds are useful as gastric acid secretion inhibitors.

  一种通式为##STR1##的新型胍基噻唑类化合物，其中R代表氢原子或较低的烷基，Y代表硫原子或亚甲基，m和n分别代表1-3的整数，A代表所示的基团##STR2##（其中R.sub.1代表氢原子、氰基、氨基甲酰基、脲基、羟基、较低的烷氧基、较低的酰基、酰胺基、芳基磺酰氨基、芳基烷基或羧甲基基团、芳基磺酰氨基、芳基烷基或羧甲基基团，R.sub.2代表氢原子、较低的烷基、较低的烯基、较低的炔基、氰基或较低的酰基，R.sub.3代表氢原子、较低的烷基、羟基或磺酰氨基），以及它们的药理学可接受的酸盐；这些化合物可用作胃酸分泌抑制剂。
• YANAGISAVA, ISAO;OTA, MITSUAKI;TAKAGI, TOKUITI
  作者：YANAGISAVA, ISAO、OTA, MITSUAKI、TAKAGI, TOKUITI

  DOI：——

  日期：——
• Novel Compound, Organic Cation Transporter 3 Detection Agent, And Organic Cation Transporter 3 Activity Inhibitor
  申请人：SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.

  公开号：US20160318886A1

  公开（公告）日：2016-11-03

  [Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound. [Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. R 1 -R 2 -R 3 -R 4 (A)