(2R,3R,4S,5R)-9-adenine ammonium salt | 132204-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R)-9-adenine ammonium salt
• 英文别名: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxymethylphosphonic acid;azane
• CAS: 132204-44-5
• 化学式: C₁₀H₁₄N₅O₇P*H₃N
• 分子量: 364.255
• InChiKey: DGGCZGZCWLRQAG-JRAMELIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  187
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (2R,4S,5R)-6-N-pivaloyl-9--2-furanyl>adenine 在 4-甲基吡啶氧化物 、 四氧化锇 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 苯硼酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.83h， 生成 (2R,3R,4S,5R)-9-adenine ammonium salt
  参考文献：
  名称：

  Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogs with potent activity against HIV

  摘要：

  Regiospecific and highly stereoselective electrophilic addition to furanoid glycals has been used as a key step in the synthesis of phosphonate isosteres of nucleoside monophosphates. Using this methodology, phosphonate analogues of 1 (ddA), 4 (d4T), and 5 (d4A) monophosphates have been prepared. Present studies have also led to the development of a scheme for the synthesis of the phosphonate isostere of adenosine monophosphate. Despite the acetal structure, phosphonate derivatives 27 and 28 were substantially more acid stable than the corresponding nucleosides 1 and 5 with respect to glycosidic bond cleavage. The phosphonates 22 and 27 exhibited a potent antiretroviral activity comparable to that of 4 (d4T).

  DOI：

  10.1021/jo00008a013

文献信息

• KIM, CHOUNG UN;LUH, BING Y.;MARTIN, JOHN C., J. ORG. CHEM., 56,(1991) N, C. 2642-2647
  作者：KIM, CHOUNG UN、LUH, BING Y.、MARTIN, JOHN C.

  DOI：——

  日期：——