1,4-Dioxa-spiro[4.5]dec-2-ylmethyl-cyanamide | 374535-64-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-Dioxa-spiro[4.5]dec-2-ylmethyl-cyanamide
• 英文别名: 1,4-Dioxaspiro[4.5]decan-3-ylmethylcyanamide
• CAS: 374535-64-5
• 化学式: C₁₀H₁₆N₂O₂
• 分子量: 196.249
• InChiKey: QHIVGRHBCGRVOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-Dioxa-spiro[4.5]dec-2-ylmethyl-cyanamide 在 ammonium hydroxide 、 氯化铵 作用下， 生成 胍那决尔
  参考文献：
  名称：

  N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors

  摘要：

  Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this guanethidine together with their N-hydroxyl derivatives were report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited Weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability tinder the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00456-5
• 作为产物：
  描述：

  N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide 在 三乙胺 、 肼 作用下， 生成 1,4-Dioxa-spiro[4.5]dec-2-ylmethyl-cyanamide
  参考文献：
  名称：

  N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors

  摘要：

  Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this guanethidine together with their N-hydroxyl derivatives were report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited Weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability tinder the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00456-5

文献信息

• Bioorg. Med. Chem. Lett. 2001, 11, 2377-2380
  作者：

  DOI：——

  日期：——