[(2R,3R,4S,5R,6R)-4-acetyloxy-6-(acetyloxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-(2,2,2-trichloroethanimidoyl)oxyoxan-3-yl] 2,2-dimethylpropanoate | 120424-64-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S,5R,6R)-4-acetyloxy-6-(acetyloxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-(2,2,2-trichloroethanimidoyl)oxyoxan-3-yl] 2,2-dimethylpropanoate
• CAS: 120424-64-8
• 化学式: C₄₃H₅₈Cl₃NO₂₆
• 分子量: 1111.28
• InChiKey: NSADHMLZDJVBKN-IYCRNOAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  73
• 可旋转键数：
  30
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  342
• 氢给体数：
  1
• 氢受体数：
  27

反应信息

• 作为反应物：
  描述：

  (2S,3R,4E)-3-O-tert-butyldiphenylsilyl-2-N-tetracosanoylsphingenine 、 [(2R,3R,4S,5R,6R)-4-acetyloxy-6-(acetyloxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-(2,2,2-trichloroethanimidoyl)oxyoxan-3-yl] 2,2-dimethylpropanoate 在 三氟甲磺酸三甲基硅酯 作用下， 以37%的产率得到[(2R,3R,4S,5R,6R)-4-acetyloxy-6-(acetyloxymethyl)-2-[(E,2S,3R)-3-[tert-butyl(diphenyl)silyl]oxy-2-(tetracosanoylamino)octadec-4-enoxy]-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxyoxan-3-yl] 2,2-dimethylpropanoate
  参考文献：
  名称：

  An efficient approach to stereoselective glycosylation of ceramide derivatives: Use of pivaloyl group as a stereocontrolling auxiliary

  摘要：

  DOI：

  10.1016/s0040-4039(00)80426-8
• 作为产物：
  描述：

  [(3R,4S,5R,6R)-2,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxyoxan-3-yl] 2,2-dimethylpropanoate 生成 [(2R,3R,4S,5R,6R)-4-acetyloxy-6-(acetyloxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4-diacetyloxy-6-(acetyloxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-(2,2,2-trichloroethanimidoyl)oxyoxan-3-yl] 2,2-dimethylpropanoate
  参考文献：
  名称：

  SATO, SUSUMU;NUNOMURA, SHIGEKI;NAKANO, TAKAHISA;ITO, YUKISHIGE;OGAWA, TOM+, TETRAHEDRON LETT., 29,(1988) N 33, C. 4097-4100

  摘要：

  DOI：