2-Hydroxy-3-carboxy-propiophenon | 35888-92-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxy-3-carboxy-propiophenon
• 英文别名: 2-hydroxy-3-propionyl-benzoic acid；propionylsalicylic acid；2-Hydroxy-3-propionylbenzoic acid；2-hydroxy-3-propanoylbenzoic acid
• CAS: 35888-92-7
• 化学式: C₁₀H₁₀O₄
• mdl: MFCD09907734
• 分子量: 194.187
• InChiKey: BNKPFZVIJZNDLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-3-carboxy-propiophenon 生成 2-羟基-3-丙酰基苯甲酸甲酯
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 2-hydroxy-3-propanoyl-5-(propanoylamino)benzoate 生成 2-Hydroxy-3-carboxy-propiophenon
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Therapeutically active benzoic acid derivatives and a process for
  申请人：Recordati S.A. Chemical and Pharmaceutical Company

  公开号：US04093648A1

  公开（公告）日：1978-06-06

  Therapeutically active 2- and 3-substituted benzoic acid derivatives having the general formula ##STR1## wherein X is OH, NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; or ##STR2## wherein X is NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; pharmacologically acceptable mineral or organic acid addition salts including quaternary ammonium salts of those compounds having a basic nitrogen atom and alkaline or alkaline earth metal salts of those compounds wherein X is OH. Compounds of the formula wherein X is amino or anilino are prepared by reacting 3-propionylsalicyclic acid or a functional derivative thereof with ammonia or an amine in an anhydrous solvent. Compounds of the formula wherein X is OH are prepared by etherifying the ethylester of 3-propionylsalicyclic acid with diethylaminoethylchloride in the presence of an acid binding agent in a ketonic solvent and thereafter hydrolyzing the ester group with a mineral acid or an alkaline earth metal hydroxide.

  具有通式 ##STR1## 的治疗活性2-和3-取代苯甲酸衍生物，其中X为OH、NH.sub.2或苯环未取代或取代为氯或4-乙氧基的苯胺基；或 ##STR2## 其中X为NH.sub.2或苯环未取代或取代为氯或4-乙氧基的苯胺基；包括具有碱性氮原子的化合物的药理学上可接受的矿物质或有机酸盐和X为OH的化合物的碱性或碱土金属盐。其中X为氨基或苯胺基的化合物是通过在无水溶剂中将3-丙酰基水杨酸或其官能衍生物与氨或胺反应制备而成。其中X为OH的化合物是通过在酮溶剂中使用酸性结合剂的情况下，以二乙氨乙基氯化物醚化3-丙酰基水杨酸的乙酯酯，并随后使用矿物质酸或碱土金属氢氧化物水解酯基团制备而成。
• 3-Propionylsalicyclic acid derivatives and process for the preparation of the same
  申请人：Yamamoto Chemical Industrial Company, Limited

  公开号：EP0105484A2

  公开（公告）日：1984-04-18

  This invention relates to derivatives of 3-propionyl. salicylic acid represented by the formula (1) wherein R represents a hydrogen atom, a lower alkyl group or a group (wherein R1 and R2 represent a lower alkyl group or R1 and R2, when taken together with the nitrogen atom to which they are attached, may form a heterocyclic ring with or without an intervening hetero atom, and n is an integer of 1 to 4.), and X represents a hydrogen atom or a halogen atom, R being the group when X is a hydrogen atom. This invention also relates to processes for preparing the same.

  本发明涉及 3-丙酰基水杨酸的衍生物，由式（1）表示 其中 R 代表氢原子、低级烷基或基团 (其中 R1 和 R2 代表低级烷基或 R1 和 R2 与它们所连接的氮原子一起可形成一个杂环，中间有或没有杂原子，n 为 1 至 4 的整数。)，X 代表氢原子或卤素原子，R 为基团 当 X 为氢原子时。 本发明还涉及制备上述物质的工艺。
• Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
  申请人：RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY

  公开号：EP0558245A1

  公开（公告）日：1993-09-01

  There are disclosed compounds of the general formula The heteroatom X is preferably oxygen, but may have other values. The group W is preferably a carbonyl group, but may have other values. The preferred heterocyclic ring is thus a 4-oxo-4H-1-benzopyran ring. This may have a wide range of R₂, R₃, R₆ and R₇ substituents. Y is a linking group, chosen from a wide range, but including -COO- , -CONH- , -O- , -SO₂- and -SO₂NH-. Z is an alkylene chain, and B is a complex amine. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts are useful for the treatment of hypertension and urinary tract troubles associated with benign prostatic hypertrophy, and for the treatment of other diseases.

  已公开的化合物通式如下 杂原子 X 最好是氧，但也可以有其他值。基团 W 最好是羰基，但也可以有其他值。因此，优选的杂环是 4-氧代-4H-1-苯并吡喃环。它可以有多种 R₂、R₃、R₆ 和 R₇ 取代基。Y 是连接基团，可选范围很广，但包括-COO-、-CONH-、-O-、-SO₂- 和-SO₂NH-。Z 是亚烷基链，B 是复合胺。这些化合物及其原药、对映体、非对映异构体、N-氧化物和药学上可接受的盐类可用于治疗与良性前列腺肥大相关的高血压和尿路问题，也可用于治疗其他疾病。
• Composition and process for increasing the keepability of Christmas trees
  申请人：Laane, Nicolaas Charles Marie

  公开号：EP0962133A1

  公开（公告）日：1999-12-08

  The invention relates to a composition and a process for increasing the keepability of Christmas trees. This prevents the loss of needles, becoming unattractive at home, in the office etc. For that purpose a composition containing at least an organic compound with at least one C6-ring which further contains optionally a carrier material and/or water. Often the cutting surface or the ball of earth is put in a solution of the composition. Preferably is the compound with a least one C6-ring a benzene derivative, such as anisole and/or benzoic acid or a derivative thereof, in particular salicylic acid or an ester thereof. Furthermore the composition may also or in addition to the above contain a terpenoid compound.

  本发明涉及一种提高圣诞树可保存性的组合物和工艺。这可以防止针叶脱落，使圣诞树在家中和办公室等场所变得不美观。为此，一种组合物至少含有一种带有至少一个 C6 环的有机化合物，其中还可选择含有一种载体材料和/或水。通常情况下，切割面或土球会被置于该组合物的溶液中。具有至少一个 C6 环的化合物最好是苯衍生物，如苯甲醚和/或苯甲酸或其衍生物，特别是水杨酸或其酯类。此外，除上述成分外，组合物还可含有萜类化合物。
• METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES
  申请人：——

  公开号：US20010051184A1

  公开（公告）日：2001-12-13

  The compound curcumin, derived from turmeric, inhibits phosphorylase kinase and, by doing so, exhibits a number of physiological effects related to the control of inflammation and cellular proliferation. However, curcumin is effective only when in solution. Curcumin is almost completely insoluble in water or in oils, but is soluble in alcohols. Accordingly, a method for treating inflammation in a mammal comprising administering curcumin in a solution containing at least one alcohol to a mammal to detectably inhibit the activity of phosphorylase kinase in the blood of the mammal or in a tissue of the mammal. The alcohol is preferably ethanol, 1-propanol, or 2-propanol; most preferably, it is ethanol. Instead of curcumin, a curcumin derivative or curcuminoid can be administered. The method can further comprise the administration of at least one additional compound that can be (1) vitamin D 3 and vitamin D 3 analogues; (2) vitamin A, vitamin A derivatives, and vitamin A analogues (3) a calmodulin inhibitor; (4) an anti-inflammatory drug; (5) a calcium channel blocker; (6) a H1 or H2 histamine blocker; (7) an antioxidant; (8) a polyphenolic compound; (9) a monoterpene; (10) genistein; (11) a soybean derived lectin; and (12) dehydrozingerone. Another aspect of the present invention is a pharmaceutical composition comprising curcumin, a curcuminoid, or a curcumin derivative in a solution containing at least one alcohol, at least one additional compound as described above, and a pharmaceutically acceptable carrier.

  姜黄素是从姜黄中提取的化合物，它能抑制磷酸化酶激酶，并由此产生一系列与控制炎症和细胞增殖有关的生理效应。不过，姜黄素只有在溶液中才有效。姜黄素几乎完全不溶于水或油，但可溶于醇。因此，一种治疗哺乳动物炎症的方法，包括给哺乳动物服用含有至少一种醇的姜黄素溶液，以检测抑制哺乳动物血液或组织中磷酸激酶的活性。醇最好是乙醇、1-丙醇或 2-丙醇；最优选的是乙醇。可以施用姜黄素衍生物或姜黄类化合物来代替姜黄素。该方法可进一步包括施用至少一种额外的化合物，可以是 (1) 维生素 D 3 和维生素 D 3 钙调蛋白抑制剂；(4) 抗炎药物；(5) 钙通道阻滞剂；(6) H1 或 H2 组胺阻滞剂；(7) 抗氧化剂；(8) 多酚化合物；(9) 单萜；(10) 遗传素；(11) 大豆衍生凝集素；(12) 去氢姜酮。本发明的另一方面是一种药物组合物，该组合物包含姜黄素、姜黄类化合物或姜黄素衍生物，其溶液含有至少一种醇、至少一种上述附加化合物和药学上可接受的载体。