2-bromoinosine | 77977-04-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-bromoinosine
• 英文别名: 2-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• CAS: 77977-04-9
• 化学式: C₁₀H₁₁BrN₄O₅
• 分子量: 347.125
• InChiKey: DENPHXKOGKDTRL-UUOKFMHZSA-N

物化性质

• 密度：
  2.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-bromoinosine 在 磷酸三甲酯 、 三氯氧磷 作用下， 反应 6.0h， 以69%的产率得到2-bromoinosine 5'-phosphate
  参考文献：
  名称：

  Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins

  摘要：

  A series of N2-substituted guanosine 5'-triphosphates was synthesized from the corresponding nucleosides. The nucleosides were prepared by treatment of N2-substituted guanines with tetra-O-acetylribose under conditions which maximized the yield of the 9-beta-guanosine isomers. These nucleotides and several sugar- and base-modified analogues of GTP were tested for their ability to bind to cellular and oncogenic forms of the GTP/GDP binding proteins, Ha-ras-p21. Several N2-substituted GTPs showed affinities higher than that of GDP itself, and the N2-[p-(n-butyl)phenyl] derivative bound to the oncogenic mutant, Leu-61 p21, twice as strongly as to the cellular protein. Changes in relative affinities of the nucleotides are discussed with reference to reported crystallographic structures of p21.

  DOI：

  10.1021/jm00108a010

文献信息

• XONSE, MIKIO;MARUMOTO, RYUDZI;JOSIOKA, JOSIO;KAVASOEH, KATSUMI
  作者：XONSE, MIKIO、MARUMOTO, RYUDZI、JOSIOKA, JOSIO、KAVASOEH, KATSUMI

  DOI：——

  日期：——