3-hydroxymethyl-1-methyl-4-quinolone | 82121-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-hydroxymethyl-1-methyl-4-quinolone
• 英文别名: 1-methyl-3-hydroxymethyl-4(1H)-quinolone；3-(hydroxymethyl)-1-methylquinolin-4-one
• CAS: 82121-04-8
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: DJIDIYHFTRCMAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxymethyl-1-methyl-4-quinolone 生成 1-methyl-4-oxo-1,4-dihydroquinoline-3-carbaldehyde
  参考文献：
  名称：

  GOLDSWORTHY, J.;ROSS, W. J.;VERGE, J. P.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-hydroxy-3-hydroxymethylquinoline 生成 3-hydroxymethyl-1-methyl-4-quinolone
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Quinolone derivatives and their use in a method of controlling an
  申请人：Lilly Industries Limited

  公开号：US04390541A1

  公开（公告）日：1983-06-28

  Compounds of the following formula are described: ##STR1## in which n is 0, 1 or 2, R.sup.1 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.

  描述了以下公式的化合物：##STR1## 其中n为0、1或2，R.sup.1为C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷硫基、C.sub.1-4烷基磺酰基、三氟甲基、卤素或硝基，R.sup.2和R.sup.3分别独立地为氢或C.sub.1-4烷基，以及它们的盐。这些化合物在治疗即时超敏反应疾病方面具有用途，并通过适当的甲酰喹啉与丙二酸、叶立德或膦酸酯的反应制备。
• 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for
  申请人：The Boots Company Limited

  公开号：US04442109A1

  公开（公告）日：1984-04-10

  Novel quinolones of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is C.sub.1-4 alkyl; and R.sub.3 is hydrogen, C.sub.1-4 alkyl, methoxy, methylthio, halo or trifluoromethyl. These compounds have antihypertensive activity and may be used for treating hypertension in mammals. The quinolones are administered in novel therapeutic compositions comprising a quinolone of the above general formula together with a pharmaceutically acceptable carrier. Processes for making the novel quinolones are described.

  一种新型喹诺酮化合物，通式为##STR1## 其中n为0、1或2；R.sub.1为C.sub.1-4烷基；R.sub.3为氢、C.sub.1-4烷基、甲氧基、甲硫基、卤素或三氟甲基。这些化合物具有降压活性，可用于治疗哺乳动物的高血压。该喹诺酮与药物可接受的载体一起组成新型治疗组合物进行给药。同时还描述了制备新型喹诺酮的方法。
• 3-Methylsulfonylmethyl-4-quinolinones useful for treating hypertension
  申请人：The Boots Company PLC

  公开号：US04447435A1

  公开（公告）日：1984-05-08

  Novel quinolones of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is C.sub.1-4 alkyl; and R.sub.3 is hydrogen, C.sub.1-4 alkyl, methoxy, methylthio, halo or trifluoromethyl. These compounds have antihypertensive activity and may be used for treating hypertension in mammals. The quinolones are administered in novel therapeutic compositions comprising a quinolone of the above general formula together with a pharmaceutically acceptable carrier. Processes for making the novel quinolones are described.

  一种新型喹诺酮化合物，其通式为##STR1##其中n为0、1或2；R.sub.1为C.sub.1-4烷基；R.sub.3为氢、C.sub.1-4烷基、甲氧基、甲基硫基、卤素或三氟甲基。这些化合物具有降压活性，可用于治疗哺乳动物的高血压。这些喹诺酮化合物可与药学上可接受的载体一起组成新的治疗组合物进行给药。还描述了制备这些新型喹诺酮化合物的方法。
• Quinolone derivatives and their use as pharmaceuticals
  申请人：Lilly Industries Limited

  公开号：EP0055068A1

  公开（公告）日：1982-06-30

  Compounds of the following formula are described: in which n is 0, 1 or 2, R1 is C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R2 and R3 are each independently hydrogen or C1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.

  描述了下式化合物： 其中 n 为 0、1 或 2，R1 为 C1-4 烷基、C1-4 烷氧基、C1-4 烷硫基、C1-4 烷磺酰基、三氟甲基、卤代或硝基，R2 和 R3 各自独立地为氢或 C1-4 烷基，以及它们的盐。这些化合物可用于治疗即刻过敏症，其制备方法是将适当的甲酰基喹啉酮与丙二酸、酰基或膦酸反应。
• GOLDSWORTHY, J.;ROSS, W. J.;VERGE, J. P.
  作者：GOLDSWORTHY, J.、ROSS, W. J.、VERGE, J. P.

  DOI：——

  日期：——