Opt.-inakt. 3-Hydroxy-1.1.4-trimethyl-cyclohexan | 99780-90-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Opt.-inakt. 3-Hydroxy-1.1.4-trimethyl-cyclohexan
• 英文别名: 2,5,5-Trimethyl-cyclohexanol；2,5,5-Trimethylcyclohexanol；2,5,5-trimethylcyclohexan-1-ol
• CAS: 99780-90-2
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: ZQNVSBUBNVRLOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Opt.-inakt. 3-Hydroxy-1.1.4-trimethyl-cyclohexan 、 diallylphosphinyl chloride 在 三乙胺 作用下， 生成 Diallylphosphinsaeure-<2,5,5-trimethyl-cyclohexylester>
  参考文献：
  名称：

  Investigation in the series of derivatives of phosphinic and phosphinous acids. VI. Esters of allylalkylphosphinic acids and their biological activity

  摘要：

  DOI：

  10.1007/bf00760828
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 sodium 作用下， 生成 Opt.-inakt. 3-Hydroxy-1.1.4-trimethyl-cyclohexan
  参考文献：
  名称：

  Hirsjaervi, Suomen Kemistilehti B, 1939, vol. 12, p. 3

  摘要：

  DOI：

文献信息

• CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS
  申请人：Meyer Imke

  公开号：US20130137710A1

  公开（公告）日：2013-05-30

  The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR 1 R 2 , wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.

  本发明涉及以下式子（I）所示的某些环己基氨基甲酸酯化合物的化妆品、皮肤科或治疗用途，优选作为抗脂肪纹活性剂。本发明还涉及包含该式（I）化合物的组合物和化妆品、皮肤科或治疗产品，这些化合物优选用于人类的脂肪纹预防和美容治疗，以及相应的方法和新型式（I）化合物。其中，A表示......，X、Y和Z分别独立地表示氢、C1-C4烷基或C2-C4烯基，其中可选地，X、Y和Z中的两个基团彼此共价结合形成二环环系统，在这样的二环环系统中，X、Y和Z中的两个基团一起优选形成具有1至4个碳原子的基团，优选为具有1至3个碳原子的碳氢基团，B表示NR1R2，其中R1表示氢或具有1至14个碳原子的有机基团，R2表示具有1至14个碳原子的有机基团，可选地，R1和R2彼此共价结合，优选使得B为3至8个成员的环。
• CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
  申请人：Vielhaber Gabriele

  公开号：US20130156710A1

  公开（公告）日：2013-06-20

  The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR 1 , R 2 , wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.

  本发明涉及以下式子(I)所示的某些环己基氨基甲酸酯化合物的化妆品、皮肤学或治疗用途，优选作为皮肤和/或头发美白活性剂。本发明还涉及含有一个或多个式(I)化合物的组合物和化妆品、皮肤学或治疗产品，适用于美白人类皮肤和/或头发以及相应的方法。本发明还涉及式(I)化合物作为药物，其用于制备用于美白人类皮肤和/或头发的制药组合物，以及式(I)的新化合物，其中A表示其中X、Y和Z彼此独立地表示氢、C1-C4烷基或C2-C4烯基，其中可选地，X、Y和Z中的两个基团在形成二环环系的情况下共价键结在一起，这样，在这样的二环环系中，X、Y和Z中的两个基团首选形成具有1到4个碳原子的基团，优选为具有1到3个碳原子的碳氢基团；B表示NR1、R2，其中R1表示氢或具有1到14个碳原子的有机基团，R2表示具有1到14个碳原子的有机基团，可选地，R1和R2彼此共价键结，优选使得B为3到8个成员的环。
• Cyclohexyl carbamate compounds as anti-ageing actives
  申请人：Symrise AG

  公开号：EP2389922A1

  公开（公告）日：2011-11-30

  The present invention relates to the cosmetic, dermatological or therapeutic use of compounds of formula (I) given below, in particular as anti-ageing actives. wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring. The invention further relates to corresponding methods and to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) and one or more further anti-ageing actives. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition and to certain novel compounds of formula (I).

  本发明涉及以下式子(I)的化合物在化妆品、皮肤科或治疗中的使用，特别是作为抗衰老活性物质。 其中， A代表 其中，X、Y和Z分别独立地表示氢、C1-C4烷基或C2-C4烯基， 其中，可选地，X、Y和Z中的两个基团在形成二环环系的同时共价键合在一起，这样，在这样的二环环系中，X、Y和Z中的两个基团一起优选形成具有1到4个碳原子的基团，优选是指1到3个碳原子的碳氢基团， B代表NR1R2， 其中， R1代表氢或具有1到14个碳原子的有机基团， R2代表具有1到14个碳原子的有机基团， 并且可选地，R1和R2共价键合在一起，优选是使B成为3到8成员环。 本发明还涉及相应的方法、包含一个或多个式(I)化合物和一个或多个进一步的抗衰老活性物质的组合物和化妆品、皮肤科或制药制剂(组合物)。本发明还涉及式(I)化合物作为药物、其用于制备制药组合物以及某些新的式(I)化合物。
• Noncross-linked polystyrene nanoencapsulation of ferric chloride: A novel and reusable heterogeneous macromolecular Lewis acid catalyst toward selective acetylation of alcohols, phenols, amines, and thiols
  作者：Ali Rahmatpour、Sara Alinejad、Ghazaleh Donyapeyma

  DOI：10.1016/j.jorganchem.2022.122264

  日期：2022.3

  non-cross-linked polystyrene matrix as the shell material via the coacervation technique. The resulting polystyrene nanoencapsulated ferric chloride was used as a novel and recyclable macromolecular Lewis acid catalyst for efficient and selective acetylation of various alcohols, phenols, amines, and thiols using acetic anhydride as the acetyl source at room temperature. The non-cross-linked polystyrene/ferric

  氯化铁首次通过凝聚技术成功纳米包封在非交联聚苯乙烯基质上作为壳材料。所得聚苯乙烯纳米包封的三氯化铁被用作一种新型且可回收的大分子路易斯酸催化剂，用于在室温下以乙酸酐为乙酰基源，对各种醇、酚、胺和硫醇进行有效和选择性的乙酰化。非交联聚苯乙烯/采用DR-UV、ATR-FT-IR、FE-SEM、TEM、EDX、ICP、DLS和TGA技术对三氯化铁复合纳米胶囊进行了表征。这种平均粒径为 558 nm 的聚合物纳米催化剂很稳定，可以通过简单的过滤从反应混合物中轻松分离、回收，并且可重复使用，Fe(III) 损失最小。发现聚苯乙烯纳米封装的 FeCl 3 (PS-NC/FeCl 3 ) 比其未封装的对应物更稳定且更具活性。此外，纳米包封催化剂具有较高的TOF。具有嵌入非交联聚苯乙烯壳中的多个氯化铁核的复合纳米胶囊表现出优异的催化活性和可重复使用性，表明纳米胶囊壳的渗透性使催化反应成为可能。
• A Novel Nanoencapsulated Zirconium(IV) Chloride Using Non-cross-linked Polystyrene as a Recyclable Lewis Acid Catalyst: Synthesis, Characterization, and Performance Towards Acylation of Alcohols and Phenols
  作者：Ali Rahmatpour、Sara Alinejad

  DOI：10.1007/s10562-022-03933-4

  日期：2022.12

  composite nanocapsules with multiple ZrCl4 cores embedded in a non-cross-linked polystyrene shell were first synthesized by coacervation technique and then this heterogenized Lewis acid, PS-NCZrCl4, as a novel and recoverable catalyst showed high efficiency for the selective catalytic acetylation of various alcohols and phenols using acetic anhydride as an acylating reagent at room temperature. The nanocapsules

  首先通过凝聚技术合成了在非交联聚苯乙烯壳中嵌入多个 ZrCl 4核的氯化锆/聚合物复合纳米胶囊，然后这种多相路易斯酸 PS-NCZrCl 4作为一种新型可回收催化剂表现出高在室温下使用乙酸酐作为酰化试剂对各种醇和酚进行选择性催化乙酰化的效率。平均粒径为 600 nm 的纳米胶囊是稳定的，并且封装的催化剂显示纳米胶囊中没有明显的金属离子损失，表明纳米胶囊提供了复合物的稳定性。线性聚苯乙烯纳米封装的 ZrCl 4在醇和酚的乙酰化中表现出优异的催化活性和可重复使用性，纳米胶囊壳的渗透性使催化反应成为可能。 图形概要 以非交联聚苯乙烯为原料，通过凝聚技术制备了一种新型纳米包封氯化锆（IV），并作为一种环境友好、可回收的多相催化剂，在室温下使用乙酸酐对各种醇和酚进行高效选择性乙酰化。