(2S,3R,4R,5R)-2-(4-amino-5-fluoro-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol | 1040273-93-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4R,5R)-2-(4-amino-5-fluoro-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
• 英文别名: 4-amino-5-fluoro-7-(2-C-methyl-β-D-ribofuranosyl)-pyrrolo[2,1-f][1,2,4]triazine；(2S,3R,4R,5R)-2-(4-amino-5-fluoro-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol；(2S,3R,4R,5R)-2-(4-amino-5-fluoropyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
• CAS: 1040273-93-5
• 化学式: C₁₂H₁₅FN₄O₄
• 分子量: 298.274
• InChiKey: OASPZQZSDLYUAH-ZIYJGFGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5-fluoro-N-methoxy-7-[(2S,3S,4R,5R)-3-methyl-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine 在 盐酸 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 反应 22.0h， 生成 (2S,3R,4R,5R)-2-(4-amino-5-fluoro-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
  参考文献：
  名称：

  WO2008/89105

  摘要：

  公开号：

文献信息

• BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
  申请人：Francom Paula

  公开号：US20100035836A1

  公开（公告）日：2010-02-11

  The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.

  本公开涉及使用和制造双环核苷和核苷酸以治疗和预防感染性和增生性疾病，包括微生物感染和癌症的方法。
• Anticancer nucleoside analogs
  申请人：BioCryst Pharmaceuticals, Inc.

  公开号：EP2535345A1

  公开（公告）日：2012-12-19

  The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.

  本发明提供了本文所述的式(I)化合物，以及包含该化合物的药物组合物，以及用于制备该化合物的合成方法和中间体。式（I）化合物可用作抗病毒剂和/或抗癌剂。
• BYCYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
  申请人：Biota Scientific Management

  公开号：EP2313102A2

  公开（公告）日：2011-04-27
• ANTIVIRAL NUCLEOSIDE ANALOGS
  申请人：Babu Yarlagadda S.

  公开号：US20100015094A1

  公开（公告）日：2010-01-21

  The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
• US8119607B2
  申请人：——

  公开号：US8119607B2

  公开（公告）日：2012-02-21