1,1a,6,10b-Tetrahydro-6-methyldibenzocyclopropazepin | 30481-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,1a,6,10b-Tetrahydro-6-methyldibenzocyclopropazepin
• 英文别名: 6-Methyl-1,1a,6,10b-tetrahydrodibenzo[b,f]cyclopropa[d]azepine；11-methyl-11-azatetracyclo[10.4.0.02,4.05,10]hexadeca-1(16),5,7,9,12,14-hexaene
• CAS: 30481-28-8
• 化学式: C₁₆H₁₅N
• 分子量: 221.302
• InChiKey: JWMVTMSJLATFRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1a,6,10b-Tetrahydro-6-methyldibenzocyclopropazepin 、 potassium permanganate 以68%的产率得到
  参考文献：
  名称：

  KAWASHIMA K.; KAWANO Y., CHEM. AND PHARM. BULL. , 1976, 24, NO 11, 2751-2760

  摘要：

  DOI：

文献信息

• Use of CNS penetrating anticancer compounds for the treatment of protozan diseases
  申请人：Dormeyer, Matthias

  公开号：EP1808173A1

  公开（公告）日：2007-07-18

  The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetrate into the CNS for treatment of late stage African sleeping sickness or cerebral malaria.

  本发明涉及通过向患者施用细胞毒性和/或细胞抑制化合物，特别是用于抗癌治疗的化合物来治疗原生动物疾病。特别是，本发明涉及使用可渗透到中枢神经系统的抗癌剂来治疗晚期非洲昏睡病或脑疟疾。
• USE OF CNS PENETRATING ANTICANCER COMPOUNDS FOR THE TREATMENT OF PROTOZOAL DISEASES
  申请人：Dormeyer Matthias

  公开号：US20110118199A1

  公开（公告）日：2011-05-19

  The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetrate into the CNS for treatment of late stage African sleeping sickness or cerebral malaria.
• [EN] USE OF CNS PENETRATING ANTICANCER COMPOUNDS FOR THE TREATMENT OF PROTOZOAL DISEASES<br/>[FR] UTILISATION DE COMPOSÉS ANTICANCÉREUX PÉNÉTRANT LE SNC POUR LE TRAITEMENT DE MALADIES PROTOZOAIRES
  申请人：DORMEYER MATTHIAS

  公开号：WO2007080116A2

  公开（公告）日：2007-07-19

  [EN] The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetrate into the CNS for treatment of late stage African sleeping sickness or cerebral malaria.
  [FR] La présente invention concerne le traitement de maladies provoquées par des protozoaires en administrant aux patients des composés cytotoxiques et/ou cytostatiques, en particulier ceux utilisés dans la thérapie anticancéreuse. En particulier, l'invention concerne l'utilisation d'agents anticancéreux capables de pénétrer dans le SNC pour le traitement de la maladie du sommeil africaine au stade tardif ou de la malaria cérébrale.