(R)-2-{(4S,5S)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-propionyl]-2,2,4-trimethyl-oxazolidin-5-yl}-propionic acid | 289622-60-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-{(4S,5S)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-propionyl]-2,2,4-trimethyl-oxazolidin-5-yl}-propionic acid
• 英文别名: (2R)-2-[(4S,5S)-2,2,4-trimethyl-3-[(2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoyl]-1,3-oxazolidin-5-yl]propanoic acid
• CAS: 289622-60-2
• 化学式: C₁₈H₃₂N₂O₆
• 分子量: 372.462
• InChiKey: CLWRHMOBVBWMGH-VOAKCMCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  96.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-2-{(4S,5S)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-propionyl]-2,2,4-trimethyl-oxazolidin-5-yl}-propionic acid 在 4-二甲氨基吡啶 、 正丁基锂 、 N,N'-二环己基碳二亚胺 作用下， 生成 ((S)-2-{(4S,5S)-5-[(R)-2-((R)-5-Isopropyl-3,3-dimethyl-2,4-dioxo-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-2,2,4-trimethyl-oxazolidin-3-yl}-1-methyl-2-oxo-ethyl)-methyl-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin

  摘要：

  The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3'-dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00533-5
• 作为产物：
  描述：

  Methyl-{(S)-1-methyl-2-oxo-2-[(4S,5S)-2,2,4-trimethyl-5-((S)-1-methyl-allyl)-oxazolidin-3-yl]-ethyl}-carbamic acid tert-butyl ester 在 ruthenium trichloride sodium periodate 作用下， 以78%的产率得到(R)-2-{(4S,5S)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-propionyl]-2,2,4-trimethyl-oxazolidin-5-yl}-propionic acid
  参考文献：
  名称：

  Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin

  摘要：

  The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3'-dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00533-5