2-formyl-1-methyl-4-vinylpyrrole | 119580-86-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-formyl-1-methyl-4-vinylpyrrole
• 英文别名: 4-Ethenyl-1-methylpyrrole-2-carbaldehyde
• CAS: 119580-86-8
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: XNUWSWGJOOHBNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-formyl-1-methyl-4-vinylpyrrole 、 丁炔二酸二甲酯 以 二氯甲烷 为溶剂， 反应 7.0h， 以30%的产率得到dimethyl 2-formyl-4,5-dihydro-1-methylindole-6,7-dicarboxylate
  参考文献：
  名称：

  Gonsalez-Rosende, Eugenia; Jones, R. Alan; Sepulveda-Arques, Jose, Synthetic Communications, 1988, vol. 18, # 14, p. 1669 - 1678

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Methyl-4-jod-2-pyrrolcarboxaldehyd 、 三丁基乙烯基锡 在 bis(triphenylphosphine)palladium(II)-chloride 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以92%的产率得到2-formyl-1-methyl-4-vinylpyrrole
  参考文献：
  名称：

  An efficient synthesis of 3-vinylpyrroles by Stille coupling reaction of 3-iodopyrroles with vinyltributyltin

  摘要：

  Several 3-vinylpyrrolic compounds with different functional groups have been synthesized by Stille coupling reaction of S-iodopyrroles with vinyltributyltin in 80-92% yields. Under the same reaction conditions it was found that 3-bromopyrroles gave the corresponding product in very poor yield, while 3-chloropyrroles were unreactive.

  DOI：

  10.1016/0040-4039(95)01459-u

文献信息

• GONZALEZ-ROSENDE, EUGENIA;JONES, R. ALAN;SEPULVEDA-ARGUES, JOSE;ZABALLOS-+, SYNTH. COMMUN., 18,(1988) N 14, C. 1669-1678
  作者：GONZALEZ-ROSENDE, EUGENIA、JONES, R. ALAN、SEPULVEDA-ARGUES, JOSE、ZABALLOS-+

  DOI：——

  日期：——
• Gonsalez-Rosende, Eugenia; Jones, R. Alan; Sepulveda-Arques, Jose, Synthetic Communications, 1988, vol. 18, # 14, p. 1669 - 1678
  作者：Gonsalez-Rosende, Eugenia、Jones, R. Alan、Sepulveda-Arques, Jose、Zaballos-Garcia, Elena

  DOI：——

  日期：——
• An efficient synthesis of 3-vinylpyrroles by Stille coupling reaction of 3-iodopyrroles with vinyltributyltin
  作者：Jianji Wang、A. Ian Scott

  DOI：10.1016/0040-4039(95)01459-u

  日期：1995.9

  Several 3-vinylpyrrolic compounds with different functional groups have been synthesized by Stille coupling reaction of S-iodopyrroles with vinyltributyltin in 80-92% yields. Under the same reaction conditions it was found that 3-bromopyrroles gave the corresponding product in very poor yield, while 3-chloropyrroles were unreactive.