semimyrtucommulone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: semimyrtucommulone
• 英文别名: 5-hydroxy-2,2,6,6-tetramethyl-4-[2-methyl-1-[2,4,6-trihydroxy-3-methyl-5-(2-methylpropanoyl)phenyl]propyl]cyclohex-4-ene-1,3-dione
• 化学式: C₂₅H₃₄O₇
• 分子量: 446.541
• InChiKey: LQOPKPCZNCPZQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 semimyrtucommulone 在 吡啶 作用下， 以45%的产率得到Acetic acid 3,5-diacetoxy-2-[1-(2-acetoxy-3,3,5,5-tetramethyl-4,6-dioxo-cyclohex-1-enyl)-2-methyl-propyl]-6-isobutyryl-4-methyl-phenyl ester
  参考文献：
  名称：

  Oligomeric Acylphloroglucinols from Myrtle (Myrtus communis)

  摘要：

  The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of. myrtle (Myrtus communis) as a 2:1 mixture of two rotamers. The known trimeric phloroglucinol myrtucommulone A (1) was also isolated and characterized spectroscopically as a silylated cyclized derivative (5). Myrtucommulone A showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while semimyrtucommulone was less active.

  DOI：

  10.1021/np010441b

文献信息

• ANTIOXIDANT COMPOSITIONS COMPRISING EXTRACTS OF MYRTLE AND ROSEMARY
  申请人：Nuraging Biotech S.r.l.

  公开号：EP2046357A1

  公开（公告）日：2009-04-15
• UTILISATION D'UN EXTRAIT DE MYRTE EN TANT QU'AGENT ANTI-BIOFILM VIS-A-VIS DE P. ACNES
  申请人：Pierre Fabre Dermo-Cosmétique

  公开号：EP2869827A1

  公开（公告）日：2015-05-13
• New alpha-glucosidase inhibitors and antibacterial compounds from Myrtus communis L.
  申请人：Rahman Attaur

  公开号：US20080269510A1

  公开（公告）日：2008-10-30

  Three new acylphloroglucinols, myrtucommulone-D (Compound 1), myrtucommulone-E (Compound 2), myrtucommulone-C (Compound 3), and a known acyphloroglucinol myrtucommulone B (Compound 4) were isolated from a methanolic extract of Myrtus communis L. The structures of compounds 1, 2 and 4 were also unambiguously determined by single X-ray diffraction analysis. The compounds 1-4 were found to be more potent α-glucosidase inhibitors than the clinically used standards, acarbose and deoxynojirimycin. The compound 3 exhibited the highest activity among all the acylphloroglucinols, with an IC 50 =35.4±1.15 μM. The compounds 1 and 2 also exhibited strong antibacterial activities.
• THERAPEUTIC POLYMERS AND METHODS OF GENERATION
  申请人：Benz Michael Eric

  公开号：US20110082266A1

  公开（公告）日：2011-04-07

  The invention describes poly(ortho ester) polymers that include at least one therapeutic compound in the polymer backbone. The therapeutic compound includes at least one phenol residue and an aliphatic alcohol residue or two or more phenolic residues.
• USE OF A MYRTLE EXTRACT AS AN ANTI-BIOFILM AGENT AGAINST P. ACNES
  申请人：PIERRE FABRE DERMO-COSMETIQUE

  公开号：US20150190447A1

  公开（公告）日：2015-07-09

  The invention relates to a dermatological composition containing a myrtle extract in a concentration that is higher than or equal to 0.01 wt.%, for the use thereof as an anti-biofilm agent against Propionibacterium acnes.