8-溴-2-[(1-甲基-4-哌啶基)氨基]-4-[(4-苯氧基苯基)氨基]吡啶并[4,3-D]嘧啶-5(6H)-酮 | 1457983-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 8-溴-2-[(1-甲基-4-哌啶基)氨基]-4-[(4-苯氧基苯基)氨基]吡啶并[4,3-D]嘧啶-5(6H)-酮
• 中文别名: FLT3抑制剂(G-749)；化合物G-749；8-溴-2-((1-甲基哌啶-4-基)氨基)-4-((4-苯氧基苯基)氨基)吡啶并[4,3-D]嘧啶-5(6H)-酮；G-749抑制剂
• 英文名称: G-749
• 英文别名: 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one；Denfivontinib；8-bromo-2-[(1-methylpiperidin-4-yl)amino]-4-(4-phenoxyanilino)-6H-pyrido[4,3-d]pyrimidin-5-one
• CAS: 1457983-28-6
• 化学式: C₂₅H₂₅BrN₆O₂
• 分子量: 521.416
• InChiKey: SXWMIXPJPNCXQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  91.4
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  8-溴-2-[(1-甲基-4-哌啶基)氨基]-4-[(4-苯氧基苯基)氨基]吡啶并[4,3-D]嘧啶-5(6H)-酮 以 乙醇 、 水 、 异丙醇 为溶剂， 反应 5.0h， 以1.85 g的产率得到8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride
  参考文献：
  名称：

  CRYSTAL POLYMORPH OF 8-BROMO-2-(1-METHYLPIPERIDIN-4-YLAMINO)-4-(4-PHENOXYPHENYLAMINO)PYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE HYDROCHLORIDE AND METHOD FOR PREPARING SAME

  摘要：

  An embodiment relates to a crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3 -d]pyrimidin-5 (6H)-one hydrochloride which can effectively suppress FLT3 and has excellent stability even in a high temperature and humid environment, and a method for preparing same.

  公开号：

  US20210292322A1

文献信息

• [EN] SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDOPYRIMIDINE SUBSTITUÉE ET LEUR UTILISATION COMME INHIBITEURS DE FLT3
  申请人：GENOSCO

  公开号：WO2013142382A1

  公开（公告）日：2013-09-26

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  公开了化学式（I）的化合物和抑制激酶（包括脾酪氨酸激酶）的方法。还公开了通过向受试者施用化学式（I）的化合物的治疗有效量来治疗激酶介导的疾病或病状的方法。
• SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS
  申请人：Oscotec, Inc.

  公开号：US20130274274A1

  公开（公告）日：2013-10-17

  Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).

  公式（I）的化合物和抑制激酶的方法，包括脾酪氨酸激酶。还公开了通过向受试者投与公式（I）的化合物的治疗有效量来治疗激酶介导疾病或状况的方法。
• Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors
  申请人：UNIVERSITÄT REGENSBURG

  公开号：US11384076B2

  公开（公告）日：2022-07-12

  The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.

  本发明涉及式（I）的小分子化合物及其作为FLT3抑制剂用于治疗各种疾病，如急性髓性白血病（AML）。本发明进一步涉及化合物的合成方法和治疗方法。
• PYRIDOPYRIMIDINONE DERIVATIVES FOR USE AS AXL INHIBITORS
  申请人：Oscotec Inc.

  公开号：EP3814350A1

  公开（公告）日：2021-05-05
• EP3842434A4
  申请人：——

  公开号：EP3842434A4

  公开（公告）日：2022-06-08