methyl 4-(aminoacetyl)phenoxyacetate | 63786-98-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 4-(aminoacetyl)phenoxyacetate
• 英文别名: Methyl 2-[4-(2-aminoacetyl)phenoxy]acetate
• CAS: 63786-98-1
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: NDRUTHFTDCUQOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 4-(azidoacetyl)phenoxyacetate 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 生成 methyl 4-(aminoacetyl)phenoxyacetate
  参考文献：
  名称：

  DD127474

  摘要：

  公开号：

文献信息

• Fibrinogen receptor antagonists and their use
  申请人：Lal Bansi

  公开号：US20070021489A1

  公开（公告）日：2007-01-25

  This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.

  本发明涉及一种新型的融合双环化合物，其一般式为(I)：其中符号在此定义，以及包含该化合物的制药组合物、制备该化合物的方法和使用该化合物的方法，单独或与其他治疗剂联合使用。该化合物是血小板糖蛋白IIb/IIIa纤维蛋白原受体复合物的拮抗剂，因此对于抑制血小板聚集和治疗血栓性疾病和其他疾病非常有用。
• FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE
  申请人：Lal Bansi

  公开号：US20100256161A1

  公开（公告）日：2010-10-07

  This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.

  本发明涉及一种新型的融合双环化合物，其一般式为(I)：其中符号的定义如下，以及包含该化合物的制药组合物，制备该化合物的方法以及使用该化合物的方法，单独或与其他治疗剂联合使用。该化合物是血小板糖蛋白IIb/IIIa纤维蛋白原受体复合物的拮抗剂，因此对于抑制血小板聚集以及治疗血栓性疾病和其他疾病具有用处。
• Blood platelet aggregation inhibitory pyridine derivatives, pharmaceutical compositions thereof, and processes for their manufacture
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0004727A2

  公开（公告）日：1979-10-17

  The invention concerns novel 1-benzyl-1,2,3,6-tetrahydropyridine derivatives of the general formula:- wherein R' is hydrogen or a (1-4C)-alkyl radical, and benzene ring A bears one or two substituents selected from combinations of halogeno, (1-4C)-alkyl, (1-4C)-alkoxy, hydroxy, nitro, cyano, carboxamido, carboxyl, [(1-4C)-alkoxy]carbonyl, hydroxymethylene, amino, (1-4C)-alkanoylamino, (1-4C)-alkylsulphonamido, [(1-4C)-alkoxy]carbonyloxy, (1-4C)-alkanoyloxy and optionally substituted benzoyloxy radicals, and their pharmaceutically acceptable salts; pharmaceutical compositions thereof; and analogy proceases for their manufacture. The tetrahydropyridine derivatives of formula I are preferably employed as their acid-addition salts and are inhibitors of the aggregation of blood platelets and as such may be of application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. Representative compounds of formula I possessing particularly good blood platelet aggregation inhibitory properties are 1-(3,4-dichloro-,4-chloro-3-hydroxy-, and 4-hydroxy-benzyl)-1,2,3,6-tetrahydropyridine, preferably as their hydrochloride salts.

  本发明涉及通式为：- 的新型 1-苄基-1,2,3,6-四氢吡啶衍生物。 (1-4C)-烷基、(1-4C)-烷氧基、羟基、硝基、氰基、羧酰胺基、羧基、[(1-4C)-烷氧基]羰基、羟基亚甲基、氨基、(1-4C)-烷酰氨基、(1-4C)-烷基磺酰胺基、[(1-4C)-烷氧基]羰氧基、(1-4C)-烷酰氧基和任选取代的苯甲酰氧基的组合，以及它们的药学上可接受的盐；它们的药物组合物；以及生产它们的类似工艺。 式 I 的四氢吡啶衍生物最好作为其酸加成盐使用，它们是血小板聚集的抑制剂，因此可用于治疗或预防血栓形成或闭塞性血管疾病。具有特别好的血小板聚集抑制特性的代表性式 I 化合物是 1-(3,4-二氯-、4-氯-3-羟基-和 4-羟基-苄基)-1,2,3,6-四氢吡啶，最好是它们的盐酸盐。
• Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0004726B1

  公开（公告）日：1981-01-28
• US4105790A
  申请人：——

  公开号：US4105790A

  公开（公告）日：1978-08-08