4-methoxy-2-methylbutan-2-amine | 889765-21-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-2-methylbutan-2-amine
• CAS: 889765-21-3
• 化学式: C₆H₁₅NO
• mdl: MFCD16127064
• 分子量: 117.191
• InChiKey: UOTJBZGEOWJGED-UHFFFAOYSA-N

物化性质

• 沸点：
  152.4±13.0 °C(Predicted)
• 密度：
  0.851±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-2-methylbutan-2-amine 、 4-chloro-2-(pyridin-4-yl)-1,7-naphthyridine 在 potassium fluoride 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以21%的产率得到N-(4-methoxy-2-methylbutan-2-yl)-2-(pyridin-4-yl)-1,7-naphthyridin-4-amine
  参考文献：
  名称：

  [EN] 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS
  [FR] COMPOSÉS HÉTÉROARYLE BICYCLIQUES FUSIONNÉS EN 6-6 ET LEUR UTILISATION COMME INHIBITEURS DE LATS

  摘要：

  公开号：

  WO2018198077A3

文献信息

• [EN] 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DERIVATIVES AND THEIR USE AS PHD INHIBITORS<br/>[FR] INHIBITEURS 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DE PHD
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2014160810A1

  公开（公告）日：2014-10-02

  The present invention provides compounds of formula (I) which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

  本发明提供了公式(I)的化合物，这些化合物可用作PHD的抑制剂，以及与HIF相关疾病的治疗方法，制备这些化合物及其中间体的药物组合物。
• NOVEL PYRAZINE DERIVATIVES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20130109665A1

  公开（公告）日：2013-05-02

  The invention relates to a compound of formula (I) wherein R 1 to R 4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament. In particular, the compound may be used as a preferential agonist of Cannabinoid Receptor 2.

  该发明涉及一种化合物，其化学式为（I），其中R1至R4的定义如描述和权利要求中所述。该化合物可以用作药物。特别地，该化合物可用作大麻素受体2的选择性激动剂。
• [EN] NOVEL PYRAZINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013060751A1

  公开（公告）日：2013-05-02

  The invention relates to a compound of formula (I), wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

  该发明涉及一种化合物，其化学式为（I），其中R1至R4的定义如描述和权利要求中所述。化合物的化学式（I）可用作药物。
• [EN] PHOSPHORUS-CONTAINING COMPOUNDS USEFUL FOR MAKING HALOGEN-FREE, IGNITION-RESISTANT POLYMERS<br/>[FR] COMPOSÉS PHOSPHORÉS UTILES POUR LA FABRICATION DE POLYMÈRES RÉSISTANT À L'INFLAMMATION ET EXEMPTS D'HALOGÈNE
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2005118604A1

  公开（公告）日：2005-12-15

  Phosphorus-containing compounds are disclosed which are obtainable by reacting: (A) at least one organophosphorus compound having a group selected from the group H-P= 0 ; the group P-H and the group P-OH; and (B) at least one compound having the following Formula (I): Formula (I) [R'(Y)m']m(X - O - R')n wherein R' is an organic group; Y is a functional group selected from hydroxy, carboxylic acid, carboxylate, acid 15 anhydride, and amine; -SH, -SO3H, -CONH2, -NHCOOR, phosphite and phosphinate groups X is a hydrocarbylene group; R' is hydrogen or a hydrocarbyl group having from 1 to 8 carbon atoms, R is alkyl or aryl group having from 1 to 12 carbon atoms; m', m and n are, independently, numbers equal to or greater than 1. These compounds are useful for making flame retardant epoxy and polyurethane resins and ignition resistant thermoplastic resins, each of which is useful for a variety of end uses requiring flame retardancy or ignition resistance. Flame retardant epoxy resins may be used to make electrical laminates. Flame retardant polyurethane is useful for making rigid polyurethane foam used in construction and flexible polyurethane foam used to make vehicle upholstery. Ignition resistant thermoplastic resins are useful for making television cabinets, computer monitors, printer housings, automotive parts, and housings and parts for appliances. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.

  本发明揭示了一种含磷化合物，其可通过反应获得：(A)至少一种有机磷化合物，该有机磷化合物具有从H-P=0组中选择的基团；P-H基团和P-OH基团；和(B)至少一种具有以下化学式(I)的化合物：化学式(I) [R'(Y)m']m(X - O - R')n，其中R'是有机基团；Y是从羟基、羧酸、羧酸盐、酸酐和胺中选择的功能基团；-SH、-SO3H、-CONH2、-NHCOOR、磷酸酯和亚磷酸盐基团；X是一个烃基烷基；R'是氢或具有1至8个碳原子的烃基基团，R是具有1至12个碳原子的烷基或芳基基团；m'、m和n分别是大于或等于1的数字。这些化合物可用于制备阻燃环氧树脂和聚氨酯树脂以及防火热塑性树脂，每种树脂都可用于各种需要阻燃性或防火性的最终用途。阻燃环氧树脂可用于制造电气层压板。阻燃聚氨酯树脂可用于制造建筑中使用的刚性聚氨酯泡沫和用于制造汽车座椅的柔性聚氨酯泡沫。防火热塑性树脂可用于制造电视柜、计算机显示器、打印机外壳、汽车零部件以及电器外壳和零部件。本发明特别适用于需要或期望低溴或低卤素含量的最终用途应用中。
• N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives
  申请人：——

  公开号：US20030236256A1

  公开（公告）日：2003-12-25

  The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or more of these organisms, by applying at least one compound of the formula (I): wherein n is 0 or 1, R 1 is halogen, alkoxy, haloalkyl, haloalkoxy or alkyl, R 2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, each of R 3 , R 4 and R 5 is, independently of the others, hydrogen, lower alkyl or halogen, and R 6 is as defined in claim 1. The invention also relates to new compounds of formula (I), their preparation, use and compositions comprising said compound.

  本发明涉及一种保护植物免受植物病原体，如线虫或特别是微生物，优选为真菌、细菌和病毒，或两种或两种以上这些生物的攻击或感染的方法，通过施用至少一种化合物的公式（I）：其中n为0或1，R1为卤素、烷氧基、卤代烷基、卤代烷氧基或烷基，R2为氢、卤素、烷基、卤代烷基、烷氧基或卤代烷氧基，R3、R4和R5中的每一个独立地为氢、较低烷基或卤素，R6如权利要求1所定义。本发明还涉及公式（I）的新化合物、其制备、使用以及包含所述化合物的组合物。