7-甲氧基-1,3-苯并恶嗪-2,4-二酮 | 37895-24-2

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 7-甲氧基-1,3-苯并恶嗪-2,4-二酮
• 中文别名: 7-甲氧基-1,3-苯并噁嗪-2,4-二酮
• 英文名称: 7-Methoxy-1,3-benzoxazine-2,4-dione
• CAS: 37895-24-2
• 化学式: C₉H₇NO₄
• mdl: MFCD07368639
• 分子量: 193.16
• InChiKey: YFURRWKTIKKJEF-UHFFFAOYSA-N

物化性质

• 密度：
  1.376±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

制备方法与用途

用途：用于制备医药中间体。

反应信息

• 作为反应物：
  描述：

  7-甲氧基-1,3-苯并恶嗪-2,4-二酮 、 、 4-(氯乙氧基)苯胺 、 乙醇 在 4-二甲氨基吡啶 ice 、 乙醇 作用下， 反应 3.0h， 生成 2-amino-N-[4-(2-chloro-ethoxy)-phenyl]-4-methoxy-benzamide
  参考文献：
  名称：

  2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones

  摘要：

  本发明涉及2-或3-(取代氨基烷氧基苯基)喹唑啉-4-酮，它们是部分雌激素激动剂，可用于治疗骨质疏松症、前列腺肥大、乳腺癌和子宫内膜癌。

  公开号：

  US05948775A1

文献信息

• 3-SUBSTITUTED-6-ARYL PYRIDINES
  申请人：Hutchinson Alan J.

  公开号：US20110281837A1

  公开（公告）日：2011-11-17

  3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I的3-取代-6-芳基吡啶化合物：其中R1、R2、R3、R8、R9、A和Ar的定义在此处。这些化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合到C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的制药组合物，以及将这些化合物用于治疗各种炎症、心血管和免疫系统疾病的用途。此外，本发明提供了标记的3-取代-6-芳基吡啶，可用作C5a受体定位的探针。
• 3-Substituted-6-Aryl Pyridines
  申请人：Hutchison Alan J.

  公开号：US20090176980A1

  公开（公告）日：2009-07-09

  3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I中的3-取代-6-芳基吡啶化合物： 其中R1、R2、R3、R8、R9、A和Ar在此定义。这些化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及在治疗各种炎症，心血管和免疫系统疾病中使用这些化合物的用途。此外，本发明提供了标记的3-取代-6-芳基吡啶，可用作C5a受体的定位探针。
• Thermographic recording material providing prints with good image density and tone having improved archivability
  申请人：AGFA-GEVAERT

  公开号：EP1245404A1

  公开（公告）日：2002-10-02

  A monosheet black and white substantially light-insensitive thermographic recording material comprising a thermosensitive element and a support, the thermosensitive element containing a substantially light-insensitive organic silver salt, a 3,4-dihydroxybenzene compound in thermal working relationship therewith and a binder, characterized in that the 3,4-dihydroxybenzene compound is an aryloxo-3,4-dihydroxybenzene compound in which the aryl-group is substituted with at least one substituent having a σm-value greater than 0; or a heteroaryloxo-3,4-dihydroxybenzene compound in which the heteroaryl group has a unified aromaticity index IA greater than 53 and is optionally substituted with at least one group selected from the group consisting of aryl, hydroxy, carboxy, sulfo, sulfoalkyl, sulfoaryl, sulfonylalkyl, sulfonylaryl, annulated aryl, annulated heteroaryl, carboxyalkyl, carboxyaryl, oxoalkyl, oxoaryl, halogen, nitro, cyano and mercapto-alkyl groups; and a thermographic recording process therefor.

  一种单片黑白基本感光热敏记录材料，包括热敏元件和支持物，热敏元件含有基本感光的有机银盐、与之有热工作关系的3，4-二羟基苯化合物和粘合剂，其特征在于3，4-二羟基苯化合物是芳氧基-3，4-二羟基苯化合物，其中芳基被至少一个取代基取代，该取代基的σm-值大于0；或杂芳氧基-3,4-二羟基苯化合物，其中杂芳基的统一芳香指数 IA 大于 53，并可选择被至少一个选自芳基的基团取代、羟基、羧基、亚砜基、亚砜烷基、亚砜芳基、磺酰基烷基、磺酰基芳基、环芳基、环杂芳基、羧基烷基、羧基芳基、氧代烷基、氧代芳基、卤素、硝基、氰基和巯基烷基所组成的组；及其热成像记录工艺。
• Toning agents for use in thermographic recording materials
  申请人：Uyttendaele Carlo

  公开号：US20060100102A1

  公开（公告）日：2006-05-11

  A compound represented by formula (I): wherein X is a carbonyl or sulfonyl group; R 2 is an alkyl, alkaryl or aryl group; and R 1 is an amino group or an N-alkyl-amino group if Y is a halogen atom, an alkyl group or a hydroxy group; and R 1 is a halogen atom, an alkyl group or a hydroxy group if Y is an amino group or an N-alkyl-amino group; and a thermographic recording material comprising a support and a thermosensitive element, the thermosensitive element comprising at least one substantially light-insensitive organic silver salt, at least one organic reducing agent therefor in thermal working relationship therewith, at least one binder and at least one compound represented by formula (I).

  由式(I)代表的化合物： 其中 X 是羰基或磺酰基； R 2 是烷基、烷芳基或芳基；以及 R 1 是氨基或 N-烷基-氨基，如果 Y 是卤素原子、烷基或羟基；以及 R 1 是卤素原子、烷基或羟基（如果 Y 是氨基或 N-烷基-氨基）；以及一种热成像记录材料，包括一个支撑体和一个热敏元件，热敏元件包括至少一种基本上对光不敏感的有机银盐、至少一种与之有热工作关系的有机还原剂、至少一种粘合剂和至少一种由式（I）表示的化合物。
• SECURITY LAMINATES FOR SECURITY DOCUMENTS
  申请人：Uyttendaele Carlo

  公开号：US20110200765A1

  公开（公告）日：2011-08-18

  A security laminate for securing a security document comprising: a) a biaxially stretched polyethylene terephthalate support; and b) a thermosensitive layer coated on the support; wherein the thermosensitive layer contains a binder, a substantially light-insensitive organic silver salt, an organic reducing agent and a toning agent selected from the group consisting of phthalimides, phthalazinones, benzoxazine diones and naphthoxazine diones. Methods for manufacturing security documents are also disclosed.