试卤灵钠盐 | 34994-50-8

• 物质功能分类: 生物化工 - 生化试剂 - 荧光成像
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 试卤灵钠盐
• 中文别名: 试菌灵；7-羟基吩噁嗪酮
• CAS: 34994-50-8
• 化学式: C12H7NNaO3
• 分子量: 236.18
• InChiKey: VYVDFIMNWPNPTO-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(lit.)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  1.62
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36,S37
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• RTECS号：
  SP7698000
• 海关编码：
  2934999090
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

制备方法与用途

生物活性染料罗丹明钠盐（NSC 12097钠盐）是一种高荧光的粉红色染料，主要用于检测ROS/RNS及第二类分析物。

文献信息

• [EN] TETRAZINE AS A TRIGGER TO RELEASE CAGED CARGO<br/>[FR] TÉTRAZINE COMME DÉCLENCHEUR AFIN DE LIBÉRER UNE CHARGE ENFERMÉE DANS UNE CAGE
  申请人：UNIV COURT UNIV OF EDINBURGH

  公开号：WO2017046602A1

  公开（公告）日：2017-03-23

  There is presented a kit comprising a masked active agent and a tetrazine trigger, the masked active agent comprising an active agent connected to a masking moiety comprising a monovinyl ether or an active agent enclosed within a cage moiety comprising a monovinyl ether or an allyl group, wherein the tetrazine trigger is configured to release the active agent from the masking moiety or the cage moiety. Methods of preparing the masked active agents, and uses of the kit are also presented.

  提供了一个套装，包括一个掩蔽活性剂和一个四氮唑触发剂，其中掩蔽活性剂包括连接到包含单乙烯醚的掩蔽基团或包含单乙烯醚或烯丙基团的笼基团的活性剂，四氮唑触发剂被配置为从掩蔽基团或笼基团中释放活性剂。还提供了制备掩蔽活性剂的方法以及套装的用途。
• Molecular probes for ascorbate detection and methods of use
  申请人：The University of Hong Kong

  公开号：US10018623B1

  公开（公告）日：2018-07-10

  Described are metal complexes for the selective detection of ascorbic acid or ascorbate. The metal complexes act as molecular sensors, and are useful in detecting ascorbate in live biological samples, commercial samples, or both. The selective ascorbate sensing involves an ascorbate-selective bond cleavage reaction. The bond cleavage is not limited to the construction of molecular sensors, but also includes other stimuli-responsive materials, i.e., materials that adopt a physical state, such as gel formation, upon ascorbate-selective bond cleavage of the metal complexes.

  描述了用于选择性检测抗坏血酸或抗坏血酸的金属配合物。这些金属配合物作为分子传感器，可用于检测活体生物样本、商业样本或两者中的抗坏血酸。选择性抗坏血酸传感涉及抗坏血酸选择性断裂键反应。这种键的断裂不仅限于构建分子传感器，还包括其他刺激响应材料，即在金属配合物的抗坏血酸选择性断裂键反应后采用物理状态（如凝胶形成）的材料。
• Novel fluorogenic substrates for beta-lactamase gene expression
  申请人：Tsien Y. Roger

  公开号：US20050118669A1

  公开（公告）日：2005-06-02

  Fluorescent substrates for beta-lactamases having the general formula shown above are provided. Z includes a fluorophore or chromophore and includes a group that may link to the lactam-containing group; R 1 and R 2 are independently selected from H, aliphatic, aromatic, alkyl, and acyl; R 4 may be H and lower alkyl; B may be H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR 5 OCO(CH 2 ) n CH 3 , —CHR 5 OCOC(CH 3 ) 3 , acylthiomethyl, acyloxy-alpha-benz, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R 5 is selected from the group consisting of H and lower alkyl; n is an integer between 0 and 10, inclusive; and A may be S, O, SO, SO 2 or CH 2 . In embodiments, the beta-lactam ring may be cleaved by a beta-lactamase enzyme effective to free a fluorophore. Methods of assaying beta-lactamase activity and monitoring expression in systems using beta-lactamase as a reporter gene are also disclosed.

  提供了具有上述一般式的β-内酰胺酶荧光底物。Z包括荧光团或色团，并包括可以连接到含内酰胺基团的基团；R1和R2独立地选择自H，脂肪族，芳香族，烷基和酰基；R4可以是H和低碳基；B可以是H，生理上可接受的盐或金属，酯基，铵阳离子，-CHR5OCO（CH2）nCH3，-CHR5OCOC（CH3）3，酰硫甲基，酰氧基-α-苯，三丁基内酯，甲氧羰氧甲基，苯基，甲硫氧基甲基，β-吗啡啉乙基，二烷基氨基乙基，和二烷基氨基羰氧甲基，其中R5选择自H和低碳基的群；n是0到10之间的整数，包括10；A可以是S，O，SO，SO2或CH2。在实施例中，β-内酰胺环可以被有效释放荧光团的β-内酰胺酶酶裂解。还公开了检测β-内酰胺酶活性和使用β-内酰胺酶作为报告基因的系统中监测表达的方法。
• REACTIVE FLUOROGENIC COMPOUND AND NANOCOMPOSITE FOR SENSING HYDROGEN SULFIDE COMPRISING THE SAME
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20190076554A1

  公开（公告）日：2019-03-14

  The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.

  本发明涉及一种用于检测硫化氢的纳米复合材料；一种制备该纳米复合材料的方法；一种用于该方法的新型反应性荧光化合物；包括该纳米复合材料的检测硫化氢的试剂盒；以及利用该纳米复合材料提供疾病诊断信息的方法，该疾病导致硫化氢异常分泌。
• Sensor Comprising Resrufin Levulinate Having Sulfite Ion Selectivity and Method for Monitoring Sulfite Ion Using the Same
  申请人：CHANG Suk-Kyu

  公开号：US20120135532A1

  公开（公告）日：2012-05-31

  The present invention relates to a sensor comprising a resorufin compound having sulfite ion selectivity and a method for detecting sulfite ions using the same. More specifically, the resorufin compound may have outstandingly increased fluorescence intensity by a deprotection reaction that a levulinyl group is cleaved with a sulfite ion to be used as a selective fluorescence sensor of turn-on type, and also represent a chromogenic change to detect sulfite ions by naked eye.

  本发明涉及一种传感器，其包括具有亚硫酸盐离子选择性的荧光素化合物，并且涉及使用该传感器检测亚硫酸盐离子的方法。更具体地说，该荧光素化合物可以通过去保护反应（即通过亚硫酸盐离子裂解丙酰丙酸酯基团）显著增加荧光强度，用作一种选择性的“开启型”荧光传感器，并且通过肉眼观察表示出色变以检测亚硫酸盐离子。