荧光兰 | 33869-21-5

• 物质功能分类: 生物化工 - 生化试剂 - 酸碱指示剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 荧光兰
• 中文别名: 间苯二酚蓝
• 英文名称: lacmoid
• 英文别名: 7-Amino-2,8-bis(2,4-dihydroxyphenyl)phenoxazin-3-one
• CAS: 33869-21-5
• 化学式: C₂₄H₁₆N₂O₆
• 分子量: 428.401
• InChiKey: ABNVFGQXCGFSFH-UHFFFAOYSA-N

物化性质

• 熔点：
  >250°C
• 沸点：
  785.7±60.0 °C(Predicted)
• 密度：
  1.58±0.1 g/cm3(Predicted)
• 溶解度：
  微溶于水、乙醚；溶于水、乙醇、甲醇、戊醇、丙酮、乙酸。几乎不溶于氯仿、苯、石油醚
• 最大波长(λmax)：
  611nm

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  2934999090

制备方法与用途

制备方法

该物质可用作酸碱指示剂和生物染色剂。

用途简介

暂无具体用途信息。

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 荧光兰 在 吡啶 作用下， 生成 7-acetoxy-2,8-bis-(2,4-diacetoxy-phenyl)-phenoxazin-3-one
  参考文献：
  名称：

  Musso,H. et al., Chemische Berichte, 1963, vol. 96, p. 1579 - 1587

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二酚 在 ammonium hydroxide 、 氧气 作用下， 反应 1008.0h， 生成 荧光兰
  参考文献：
  名称：

  Musso,H. et al., Chemische Berichte, 1963, vol. 96, p. 1579 - 1587

  摘要：

  DOI：

文献信息

• Structure-based peptide inhibitors of P53 aggregation as a new approach to cancer therapeutics
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10400010B2

  公开（公告）日：2019-09-03

  This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53 amyloidogenic aggregation or restores proper folding of the misfolded protein. Methods of using the inhibitory peptide or CPP inhibitor (e.g. to treat subjects having tumors that comprise aggregated p53) are described.

  本发明涉及一种抑制肽或CPP抑制剂，它能特异性地与具有异常构象（如聚集或错误折叠）的p53结合，并抑制p53的淀粉样聚集或恢复错误折叠蛋白的正常折叠。本文描述了使用抑制肽或 CPP 抑制剂（例如治疗具有包含聚集 p53 的肿瘤的受试者）的方法。
• Structure-based peptide inhibitors of alpha-synuclein aggregation
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10815271B2

  公开（公告）日：2020-10-27

  This invention relates to inhibitory peptides which bind to α-synuclein molecules and inhibit α-synuclein amyloidogenic aggregation, α-synuclein cytotoxicity, and spread of α-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by α-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.

  本发明涉及与α-突触核蛋白分子结合并抑制α-突触核蛋白淀粉样聚集、α-突触核蛋白细胞毒性和α-突触核蛋白扩散的抑制肽。本文介绍了抑制肽的制造和使用方法（例如治疗由α-突触核蛋白介导的病症或疾病，如帕金森病、路易体痴呆或MSA）。
• Exterior electrochromic reflective mirror element for a vehicular rearview mirror assembly
  申请人：Varaprasad V. Desaraju

  公开号：US20070184284A1

  公开（公告）日：2007-08-09

  An exterior electrochromic reflective mirror element for a vehicular exterior rearview mirror assembly comprises an electrochromic cross-linked polymeric solid film disposed between a first substrate and a second substrate. The electrochromic cross-linked polymeric solid film contacts a transparent conductive layer of the first substrate and a conductive layer comprising a metallic reflective layer of the second substrate. A visual indicator display is disposed to the rear of said second substrate and is part of a blind spot detection and display system and is actuated to emit light responsive to a detection of another overtaking vehicle in a side lane. Light emitted by the visual indicator display passes through the second substrate, through the electrochromic cross-linked polymeric solid film and through the first substrate to be viewed by a driver of the vehicle equipped with the exterior electrochromic reflective mirror element.
• VEHICULAR EXTERIOR MIRROR
  申请人：Varaprasad V. Desaraju

  公开号：US20080094685A1

  公开（公告）日：2008-04-24

  An exterior mirror suitable for use in a vehicular exterior rearview mirror assembly includes a reflective mirror element having a light transmitting substrate with a mirror reflector having a metallic reflective layer coated thereon. A visual indicator display is disposed to the rear of the light transmitting substrate and actuated to emit light when powered. Light emitted by light sources of the display passes through the light transmitting substrate so as to be viewed by a driver of the vehicle equipped with the reflective mirror element. The mirror element has portions of the metallic reflective layer at least partially removed by laser scribing to establish at least partially light transmissive portions of the mirror reflector so that light emitted by light sources, when powered, passes through the respective at least partially light transmissive portions to be viewed by a viewer viewing from the front of the reflective mirror element.
• EXTERIOR REFLECTIVE MIRROR ELEMENT FOR A VEHICULAR REARVIEW MIRROR ASSEMBLY
  申请人：Varaprasad Desaraju V.

  公开号：US20100053723A1

  公开（公告）日：2010-03-04

  An exterior reflective mirror element suitable for a vehicle includes a transparent glass substrate having a reflector and a visual indicator display disposed to the rear of the substrate. The visual indicator display may be part of a blind spot detection and display system of the vehicle wherein the visual indicator display is actuated to emit light responsive to a detection by a blind spot detection detector of the equipped vehicle of an overtaking vehicle in a side lane adjacent the side of the equipped vehicle. The visual indicator display includes at least a first indicator at a first location to the rear of the exterior reflective mirror element. A first portion of the reflector may be at least partially removed at the first location in order to establish an at least partially transmissive first portion of the exterior reflective mirror element at the first location.