(Z)-2-((2-butyl-1-phenylquinolin-4(1H)-ylidene)methyl)-3-methylbenzo[d]thiazol-3-ium iodide | 161057-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (Z)-2-((2-butyl-1-phenylquinolin-4(1H)-ylidene)methyl)-3-methylbenzo[d]thiazol-3-ium iodide
• 英文别名: 2-[(2-butyl-1-phenylquinolin-1-ium-4-yl)methylidene]-3-methyl-1,3-benzothiazole;iodide
• CAS: 161057-80-3
• 化学式: C₂₈H₂₇N₂S*I
• 分子量: 550.506
• InChiKey: PIEFTRUOZSPQEK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-2-((2-butyl-1-phenylquinolin-4(1H)-ylidene)methyl)-3-methylbenzo[d]thiazol-3-ium iodide 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以83%的产率得到(Z)-2-((2-butyl-1-phenylquinolin-4(1H)-ylidene)methyl)-3-methyl-2,3-dihydrobenzo[d]thiazole
  参考文献：
  名称：

  WO2013/148038

  摘要：

  公开号：

文献信息

• Modified Nucleic Acid Binding Cyanine Dyes for the Detection of Reactive Oxygen Species
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20150079622A1

  公开（公告）日：2015-03-19

  Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

  本文公开了一种通过传统荧光显微镜、荧光光谱学、流式细胞术和/或高内容成像检测反应性氧化物种（ROS）的化合物、组合物、方法和试剂盒。本文所披露的化合物是新型的还原核酸结合青烯染料，这些染料是探针，用于检测ROS并测量体内和/或体外细胞中的氧化应激。本文还描述了制备新型还原染料，即ROS探针，用于所披露的组合物、方法和试剂盒的过程。
• MODIFIED NUCLEIC ACID BINDING CYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES
  申请人：Life Technologies Corporation

  公开号：EP2831179B1

  公开（公告）日：2016-04-20
• A KIT COMPRISING MODIFIED NUCLEIC ACID BINDING CYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES
  申请人：Life Technologies Corporation

  公开号：EP3056548B1

  公开（公告）日：2017-05-10
• US9518981B2
  申请人：——

  公开号：US9518981B2

  公开（公告）日：2016-12-13
• [EN] MODIFIED NUCLEIC ACID BINDING CYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES<br/>[FR] COLORANTS CYANINES SE LIANT À DES ACIDES NUCLÉIQUES MODIFIÉS POUR LA DÉTECTION DE DÉRIVÉS RÉACTIFS DE L'OXYGÈNE
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2013148038A1

  公开（公告）日：2013-10-03

  Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.