methyl 1-(2-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxylate | 1254180-80-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 1-(2-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxylate
• 英文别名: dimethyl 1-[(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(benzoyloxymethyl)-3-methyloxolan-2-yl]triazole-4,5-dicarboxylate
• CAS: 1254180-80-7
• 化学式: C₃₃H₂₉N₃O₁₁
• 分子量: 643.607
• InChiKey: RPORGXXXXFGULE-MOAOCXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  47
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  171
• 氢给体数：
  0
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  methyl 1-(2-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxylate 在 氨 作用下， 以 甲醇 为溶剂， 以71%的产率得到1-(2-methyl-β-D-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxamide
  参考文献：
  名称：

  Synthesis of 2′-C-Methyl Ribonucleoside Analogues with Modified Heterocyclic Base Moieties

  摘要：

  Recently, 2'-C-methyl nucleoside analogues have been reported to exhibit potent anti-hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2'-C-methyl ribonucleoside analogues.

  DOI：

  10.1080/00397910903349984
• 作为产物：
  描述：

  1-azido-2-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 、 丁炔二酸二甲酯 以 乙二醇二甲醚 为溶剂， 以57%的产率得到methyl 1-(2-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,3-triazole-4,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of 2′-C-Methyl Ribonucleoside Analogues with Modified Heterocyclic Base Moieties

  摘要：

  Recently, 2'-C-methyl nucleoside analogues have been reported to exhibit potent anti-hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2'-C-methyl ribonucleoside analogues.

  DOI：

  10.1080/00397910903349984