2-bromo-5-isopropoxypyrazine | 959238-74-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-5-isopropoxypyrazine
• 英文别名: 2-bromo-5-propan-2-yloxypyrazine
• CAS: 959238-74-5
• 化学式: C₇H₉BrN₂O
• 分子量: 217.065
• InChiKey: OWLUGZXLKGHHNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromo-5-isopropoxypyrazine 、 N-[3-(4-hydroxyphenyl)-1-methylpropyl]acetamide 在 copper(l) iodide 、 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.5h， 生成 N-{3-[4-(5-isopropoxypyrazin-2-yloxy)phenyl]-1-methylpropyl}acetamide
  参考文献：
  名称：

  Identification and Synthesis of Novel Inhibitors of Acetyl-CoA Carboxylase with in Vitro and in Vivo Efficacy on Fat Oxidation

  摘要：

  Acetyl CoA carboxylase isoforms 1 and 2 (ACC1/2) are key enzymes of fat utilization and their inhibition is considered to improve aspects of the metabolic syndrome. To identify pharmacological inhibitors of ACC1/2, a high throughput screen was performed which resulted in the identification of the lead compound 3 (Gargazanli, G.; Lardenois, P.; Frost, J.; George, P. Patent WO9855474 A1, 1998) as a moderate selective ACC2 inhibitor. Optimization of 3 led to 4m (Zoller, G.; Schmoll, D.; Mueller, M.; Haschke, G.; Focken, I. Patent WO2010003624 A2, 2010) as a submicromolar dual ACC1/2 inhibitor of the rat and human isoforms. 4m possessed favorable pharmacokinetic parameters. This compound stimulated fat oxidation in vivo and reduced plasma triglyceride levels in a rodent model after subchronic administration. 4m is a suitable tool compound for the elucidation of the pharmacological potential of ACC1/2 inhibition.

  DOI：

  10.1021/jm101179e

文献信息

• METHOD FOR PRODUCING 2-SUBSTITUTED-3-ETHYLSULFONYLPYRIDINE COMPOUND AND LIKE
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20200385361A1

  公开（公告）日：2020-12-10

  The present invention provides an intermediate compound for preparing a 2-substituted-3-ethylsulfonylpyridine compound, and a novel process for preparing the 2-substituted-3-ethylsulfonylpyridine compound. The present invention provides also a process for preparing a compound represented by formula (2), which comprises a step (a): a step of reacting of 3-ethylsulfonylpyridine N-oxide with a compound represented by formula (1) (wherein X represents a chlorine atom etc., Q represents a C1-3 alkoxy group optionally substituted with one or more fluorine atoms, etc.) in the presence of one or more compounds selected from Group P, a carboxylic acid or a carboxylate salt, a base, and a palladium compound or a nickel compound in a solvent to obtain a compound represented by formula (2), Group P: a group consisting of the following compounds: a compound represented by formula (4): R 3 P (wherein R represents an alkyl group having 1 to 6 carbon atoms, etc.), etc.; as well as a process for preparing a compound represented by formula (3), which comprises the step (a) and a step (b): a step of subjecting the compound represented by formula (2) to a reduction reaction to obtain the compound represented by formula (3).

  本发明提供了一种制备2-取代-3-乙基磺酰基吡啶化合物的中间体化合物，以及一种新的制备2-取代-3-乙基磺酰基吡啶化合物的方法。本发明还提供了一种制备由公式（2）表示的化合物的方法，其中包括步骤（a）：将3-乙基磺酰基吡啶N-氧化物与由公式（1）表示的化合物（其中X表示氯原子等，Q表示可选地取代有一个或多个氟原子的C1-3烷氧基等）在溶剂中，与来自P组中选择的一个或多个化合物，包括羧酸或羧酸盐，碱，钯化合物或镍化合物反应，以得到由公式（2）表示的化合物。P组：由以下化合物组成的一组化合物：由公式（4）表示的化合物：R3P（其中R表示具有1至6个碳原子的烷基等）。本发明还提供了一种制备由公式（3）表示的化合物的方法，其中包括步骤（a）和步骤（b）：将由公式（2）表示的化合物进行还原反应，以得到由公式（3）表示的化合物。
• HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THE USE THEREOF
  申请人：Zoller Gerhard

  公开号：US20110183998A1

  公开（公告）日：2011-07-28

  Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.

  杂环衍生物、其制备方法、包含这些化合物的药物和其用途。本发明涉及式I中的化合物，其中基团R1、R2、R3、R4、W、A、B、D、E、G、L、M、R、T和Y具有所述的含义，并且其生理上可耐受的盐。该化合物适用于例如代谢综合征、胰岛素抵抗、肥胖和糖尿病的治疗。
• Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
  申请人：Zoller Gerhard

  公开号：US08470841B2

  公开（公告）日：2013-06-25

  Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, T and Y have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example for the treatment of the metabolic syndrome, insulin resistance, obesity and diabetes.

  杂环衍生物，其制备方法，包含这些化合物的药物和其用途。本发明涉及式I的化合物，其中基团R1，R2，R3，R4，W，A，B，D，E，G，L，M，R，T和Y具有所述的含义，并且其生理耐受盐。这些化合物适用于例如治疗代谢综合征，胰岛素抵抗，肥胖和糖尿病。
• METHOD FOR PRODUCING 2-SUBSTITUTED-3-ETHYLSULFONYL PYRIDINE COMPOUND AND LIKE
  申请人：Sumitomo Chemical Company Limited

  公开号：EP3722289A1

  公开（公告）日：2020-10-14

  The present invention provides an intermediate compound for preparing a 2-substituted-3-ethylsulfonylpyridine compound, and a novel process for preparing the 2-substituted-3-ethylsulfonylpyridine compound. The present invention provides also a process for preparing a compound represented by formula (2), which comprises a step (a): a step of reacting of 3-ethylsulfonylpyridine N-oxide with a compound represented by formula (1) (wherein X represents a chlorine atom etc., Q represents a C1-3 alkoxy group optionally substituted with one or more fluorine atoms, etc.) in the presence of one or more compounds selected from Group P, a carboxylic acid or a carboxylate salt, a base, and a palladium compound or a nickel compound in a solvent to obtain a compound represented by formula (2), Group P: a group consisting of the following compounds: a compound represented by formula (4): R3P (wherein R represents an alkyl group having 1 to 6 carbon atoms, etc.), etc.; as well as a process for preparing a compound represented by formula (3), which comprises the step (a) and a step (b) : a step of subjecting the compound represented by formula (2) to a reduction reaction to obtain the compound represented by formula (3).

  本发明提供了一种制备 2-取代-3-乙基磺酰基吡啶化合物的中间体化合物，以及一种制备 2-取代-3-乙基磺酰基吡啶化合物的新工艺。本发明还提供了一种制备由式（2）代表的化合物的工艺，该工艺包括步骤（a）：3-乙基磺酰基吡啶 N-氧化物与由式（1）代表的化合物反应的步骤（其中 X 代表氯原子等、Q 代表任选被一个或多个氟原子取代的 C1-3 烷氧基等）在一种或多种选自 P 组的化合物、羧酸或羧酸盐、碱和钯化合物或镍化合物存在下，在溶剂中反应，得到式（2）代表的化合物，P 组：由下列化合物组成的一组：式（4）代表的化合物：R3P(其中 R 代表具有 1 至 6 个碳原子的烷基等)等；以及制备式(3)所代表的化合物的工艺，其包括步骤(a)和步骤(b)：将式(2)所代表的化合物进行还原反应以得到式(3)所代表的化合物的步骤。
• [EN] HETEROCYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THE USE THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES, LEURS PROCÉDÉS DE PRÉPARATION, MÉDICAMENTS COMPRENANT LESDITS COMPOSÉS ET LEUR UTILISATION
  申请人：SANOFI AVENTIS

  公开号：WO2010003624A3

  公开（公告）日：2010-04-22